Triglyceride lipolysis driven by glucose restriction triggers liquid-crystalline phase transitions and proteome remodeling of lipid droplets
S. Rogers, L. Gui, A. Kovalenko, V. Zoni, M. Carpentier, K. Ramji, K. Ben Mbarek, A. Bacle, P. Fuchs, P. Campomanes, E. Reetz, N. O. Speer, E. Reynolds, A. R. Thiam, S. Vanni, , W. M. Henne
The paper shows glucose restriction induces liquid-crystalline phase transitions in lipid droplets by promoting TG lipolysis, which alters lipid composition and remodels the proteome.
bioRxiv · Apr 15, 2022Cell Biology