S. Vanni

An acylated N-terminus and a conserved loop regulate the activity of the ABHD17 de-acylase

This study identifies two regulatory elements in ABHD17 enzymes that modulate their activity through S-acylation and membrane interactions.

Unbiased MD simulations characterize lipid binding pockets in lipid transfer proteins

This study uses unbiased MD simulations to identify lipid binding pockets in LTPs, providing insights into lipid entry pathways for bridge-like LTPs.

Improved Protein Model in SPICA Force Field

This paper improves the SPICA force field to better simulate proteins, including IDPs and peripheral proteins, by introducing secondary structure-dependent nonbonded parameters and re-optimizing interactions.

Lipid scrambling is a general feature of protein insertases

The paper shows lipid scrambling is a general feature of protein insertases, suggesting they may function as scramblases in membrane dynamics.

CryoEM architecture of a native stretch-sensitive membrane microdomain

This study determines the cryo-EM structure of native yeast eisosomes, revealing lipid organization and dynamic stretching mechanisms in membrane microdomains.

Rescaling protein-protein interactions improves Martini 3 for flexible proteins in solution

This study improves the Martini 3 model by reducing protein-protein interaction strength, enhancing accuracy for flexible proteins in solution and with lipid membranes.

Conformational dynamics of lipid transfer domains provide a general framework to decode their functional mechanism.

This study uses molecular simulations to show that lipid transfer domains (LTDs) from different LTP families share conserved dynamical features that correlate with their functional mechanism.

Malonyl-CoA is an ancient physiological ATP-competitive mTORC1 inhibitor

The paper shows malonyl-CoA inhibits mTORC1 by competing with ATP, linking lipid biosynthesis to cellular growth regulation in yeast and mammals.

Triglyceride lipolysis driven by glucose restriction triggers liquid-crystalline phase transitions and proteome remodeling of lipid droplets

The paper shows glucose restriction induces liquid-crystalline phase transitions in lipid droplets by promoting TG lipolysis, which alters lipid composition and remodels the proteome.

Supramolecular architecture of the ER-mitochondria encounter structure in its native environment

The paper determines the supramolecular architecture of the ERMES complex in yeast using integrative structural biology methods, revealing its role in lipid transfer between ER and mitochondria.

Re-charging your fats: Charmm36 parameters for neutral lipids triacylglycerol and diacylglycerol

The paper develops new CHARMM36 parameters for triacylglycerols and diacylglycerols to better reproduce their interfacial properties and behavior in lipid assemblies.

Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure

This study uses molecular dynamics simulations to show that seipin clusters triglycerides and diacylglycerol in its ring-like structure, promoting lipid droplet formation by remodeling ER membranes.

Lipid droplet biogenesis is driven by a liquid-liquid phase separation.

The paper shows that lipid droplet formation results from liquid-liquid phase separation, influenced by ER membrane properties and lipid composition.

Conserved function of ether lipids and sphingolipids in the early secretory pathway

The paper identifies hypersensitive mutants in lipid biosynthesis and trafficking genes in sphingolipid-depleted cells and shows coordinate regulation of ether and sphingolipids.

Feedback between membrane tension, lipid shape and curvature in the formation of packing defects

The paper investigates how membrane tension, lipid shape, and curvature interact to influence lipid packing defects and membrane deformation through ALPS binding and conical lipid effects.