Author

L. Gui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 7 Biophysics· 1 Physiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 8 Approach:experimental assay· 8 Assay:proteomics· 6 Research Focus:cell signaling & trafficking· 5 Assay:imaging· 4 Approach:microscopy & imaging analysis· 4 Assay:cryo-EM· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

D. Nicastro· 7 shared E. Reetz· 4 shared S. Rogers· 3 shared A. Kovalenko· 2 shared G. Fu· 2 shared J. Sakizadeh· 2 shared M. E. Porter· 2 shared R. Bower· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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7 shared papersCell Biology

D. Nicastro

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

The ciliary MBO2 complex targets assembly of inner arm dynein b and reveals additional doublet microtubule asymmetries

G. Fu, K. Augspurger, J. Sakizadeh, J. Reck, R. Bower, D. Tritschler, L. Gui, D. Nicastro, M. E. Porter

The paper identifies the MBO2 complex as a regulator of inner arm dynein b assembly in cilia and reveals its structural organization on doublet microtubules.

bioRxiv · Jul 31, 2023 · PreprintCell Biology

Boosting wheat functional genomics via indexed EMS mutant library of KN9204

D. Wang, Y. Li, H. Wang, Y. Xu, Y. Yang, Y. Zhou, Z. Chen, Y. Zhou, L. Gui, Y. Guo, C. Zhou, W. Tang, S. Zheng, L. Wang, X. Guo, , J. Xiao

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

bioRxiv · Dec 5, 2022Plant Biology

Cryo-tomography reveals rigid-body motion and organization of apicomplexan invasion machinery

L. Gui, W. J. O'Shaughnessy, K. Cai, E. Reetz, M. L. Reese, D. Nicastro

This study uses cryo-electron tomography to show that the apical complex in apicomplexan parasites moves as a rigid body, with the conoid structure remaining unchanged during protrusion and retraction.

bioRxiv · Apr 23, 2022 · PreprintBiophysics

Triglyceride lipolysis driven by glucose restriction triggers liquid-crystalline phase transitions and proteome remodeling of lipid droplets

S. Rogers, L. Gui, A. Kovalenko, V. Zoni, M. Carpentier, K. Ramji, K. Ben Mbarek, A. Bacle, P. Fuchs, P. Campomanes, E. Reetz, N. O. Speer, E. Reynolds, A. R. Thiam, S. Vanni, , W. M. Henne

The paper shows glucose restriction induces liquid-crystalline phase transitions in lipid droplets by promoting TG lipolysis, which alters lipid composition and remodels the proteome.

bioRxiv · Apr 15, 2022Cell Biology

Three-dimensional cilia structures from animals' closest unicellular relatives, the Choanoflagellates

J. M. Pinskey, A. Lagisetty, L. Gui, N. Phan, E. Reetz, G. Fu, D. Nicastro

This study uses cryo-electron tomography to analyze cilia structures in Choanoflagellates, revealing features more similar to metazoan cilia than to those of other unicellular organisms.

bioRxiv · Feb 24, 2022 · PreprintCell Biology

Liquid-crystalline lipid phase transitions in lipid droplets selectively remodel the LD proteome

S. Rogers, L. Gui, A. Kovalenko, E. Reetz, D. Nicastro, W. M. Henne

The paper shows glucose restriction induces liquid-crystalline lipid phase transitions in lipid droplets, which selectively remodel the LD proteome and affect ER-LD transport.

bioRxiv · Aug 30, 2021 · PreprintCell Biology

Glucose restriction drives spatial re-organization of mevalonate metabolism and liquid-crystalline lipid droplet biogenesis

S. Rogers, H. Hariri, L. Gui, N. E. Wood, N. Wood, D. M. Nicastro, M. M. Henne

The paper shows that glucose restriction causes yeast to reorganize mevalonate metabolism at nucleus-vacuole junctions, enhancing lipid droplet formation with liquid-crystalline properties.

bioRxiv · Aug 29, 2020 · PreprintCell Biology

Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex

L. Gui, K. Song, D. Tristchler, R. Bower, Y. Si, A. Dai, K. Augsperger, J. Sakizadeh, M. Grzemska, T. Ni, M. E. Porter, D. Nicastro

This study uses cryo-electron tomography to determine the structure of the N-DRC in Chlamydomonas flagella and identifies key subunit interactions and assembly requirements.

bioRxiv · Jun 27, 2019Cell Biology

Tetrahymena RIB72A and RIB72B are Microtubule Inner Proteins in the ciliary doublet microtubules

D. J. Stoddard, Y. Zhao, B. A. Bayless, L. Gui, P. Louka, D. Dave, S. Suryawanshi, R. F.- X. Tomasi, P. Dupuis-Williams, C. N. Baroud, J. Gaertig, M. Winey, D. Nicastro

The paper identifies RIB72A and RIB72B as Microtubule Inner Proteins in Tetrahymena ciliary doublet microtubules and shows their role in ciliary structure and motility.

bioRxiv · Jun 28, 2018Cell Biology

S-Nitrosylation of STIM1 by neuronal nitric oxide synthase inhibits store-operated Ca2+ entry

L. Gui, J. Zhu, X. Lu, S. M. Sims, W.-Y. Lu, P. B. Stathopulos, Q. Feng

This study shows that S-nitrosylation of STIM1 by nNOS inhibits SOCE in cardiomyocytes by stabilizing the luminal domain and preventing oligomerization.

bioRxiv · Apr 18, 2018Physiology