Author

A. Barka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

K. N. Berrios· 2 shared R. M. Kohli· 2 shared E. K. Schutsky· 1 shared J. B. Parker· 1 shared J. C. Serrano· 1 shared J. Gill· 1 shared J. Shi· 1 shared K. S. Gajula· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

K. N. Berrios

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2 papers

Recent·Most cited

Cooperativity between Cas9 and hyperactive AID establishes broad and diversifying mutational footprints in base editors

K. N. Berrios, A. Barka, J. Gill, J. C. Serrano, P. F. Bailer, J. B. Parker, N. H. Evitt, K. S. Gajula, J. Shi, R. M. Kohli

This study develops hyperactive base editors by exploring Cas9 and AID cooperation, revealing mechanisms that expand mutational diversity and efficiency in base editing.

bioRxiv · Dec 3, 2022Biochemistry

The base-editing enzyme APOBEC3A catalyzes cytosine deamination in RNA with low proficiency and high selectivity

A. Barka, K. N. Berrios, P. Bailer, E. K. Schutsky, T. Wang, R. M. Kohli

This study investigates how APOBEC3A preferentially targets DNA over RNA by analyzing substrate selectivity and deamination efficiency.

bioRxiv · Nov 26, 2021Biochemistry