Kinetic stabilization of translation-repression condensates by a neuron-specific microexon
C. Garcia-Cabau, A. Bartomeu, G. Tesei, K. C. Cheung, J. Pose-Utrilla, S. Pico, A. Balaceanu, B. Duran-Arque, M. Fernandez-Alfara, J. Martin, C. De Pace, L. Ruiz-Perez, J. Garcia, G. Battaglia, J. J. Lucas, , X. Salvatella
The paper shows that a neuron-specific microexon in CPEB4 stabilizes translation-repression condensates by competing with aggregation, enabling reversible regulation of gene expression in neurons.
bioRxiv · Mar 19, 2023Biophysics