A. Basant

CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes

This study shows CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes, with CK-869 uniquely affecting ArpC1B and Arp3-containing complexes, impacting phagocytosis and migration in macrophages.

Kinesin-1 transports morphologically distinct intracellular virions during vaccinia infection

This study shows kinesin-1 transports two distinct vaccinia virion forms, IMV and IEV, with different speeds and motor complex numbers, and demonstrates the importance of kinesin-1 for viral spread.

The level of Nck rather than N-WASP determines the rate of actin-based motility of Vaccinia

The paper quantifies viral and host proteins involved in Vaccinia virus actin-based motility, finding that Nck levels, not N-WASP, determine virus movement speed.

The Relative Binding Position of Nck and Grb2 Adaptors Dramatically Impacts Actin-Based Motility of Vaccinia Virus

The study shows that specific spatial arrangements of pTyr motifs in viral proteins are necessary for efficient actin-based motility and spread of Vaccinia virus.

PLK1 plays dual roles in centralspindlin regulation during cytokinesis

This study identifies two pathways for cytokinesis initiation in human cells, showing PLK1 and Aurora B have distinct roles in regulating RhoA activation and centralspindlin function.