L. Cao

Cold seeps are hotspots of deep-sea nitrogen-loss driven by microorganisms across 21 phyla

This study identifies cold seeps as significant nitrogen-loss hotspots, revealing diverse microbial communities and active nitrogen-loss genes across multiple phyla.

Design of High Affinity Binders to Convex Protein Target Sites

This paper designs high-affinity proteins that bind to convex protein sites using geometrically matching concave scaffolds, achieving low nanomolar to picomolar affinities.

Profiling trace organic chemical biotransformation genes, enzymes and associated bacteria in microbial model communities

The paper investigates biotransformation of trace organic chemicals by microbial communities, identifying key genes, enzymes, and bacteria involved in their degradation.

PROTAC-mediated dual degradation of BCL-xL and BCL-2 is a highly effective therapeutic strategy in small-cell lung cancer

This paper evaluates a dual BCL-xL/BCL-2 degrader, 753b, showing it effectively reduces tumor viability and growth in SCLC models while avoiding platelet toxicity seen with navitoclax.

Reductive dehalogenation by diverse microbes is central to biogeochemical cycles in deep-sea cold seeps

The paper investigates reductive dehalogenation in deep-sea cold seeps, identifying diverse RDases and their ecological role in biogeochemical cycles.

The J-Like Protein ARC6 Regulates Chloroplast FtsZ-Ring Assembly through Fine-tuning ARC3 Activity in Arabidopsis

The paper identifies ARC6 as a regulator of chloroplast division by modulating ARC3 activity through its J-like domain, ensuring proper Z-ring assembly and positioning.

CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes

This study shows CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes, with CK-869 uniquely affecting ArpC1B and Arp3-containing complexes, impacting phagocytosis and migration in macrophages.

Structure of scavenger receptor SCARF1 and its interaction with lipoproteins

This study determines the structure of SCARF1 and identifies its ligand recognition mechanism, revealing key residues and shared binding sites for modified LDLs and bacterial teichoic acids.

USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase transition potential

This study identifies USP10 as a novel regulator of β-catenin through dual mechanisms involving deubiquitination and phase separation, with implications for cancer treatment.

Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia

The paper identifies PIK3R1 loss as a resistance mechanism to NOTCH inhibition in T-ALL and shows CDK4/6 inhibitors synergize with NOTCH inhibitors.

Regeneration of actin filament branches from the same Arp2/3 complex

The paper shows that Arp2/3 complex can re-nucleate actin branches without NPF activation after debranching, suggesting a self-repair mechanism for actin networks.

Microsporidia Ser/Thr Protein Phosphatase PP1 Targets DCs MAPK Pathway and Impairs Immune Functions

This study shows that Microsporidia infection impairs dendritic cell functions by targeting the p38/MAPK pathway via PP1, increasing susceptibility to secondary infections.

Predictive evolutionary modelling for influenza virus by site-based dynamics of mutations

A computational model predicts influenza virus evolution and aids in vaccine strain selection by modeling site-wise mutation dynamics.

Cooperation between bacteriocytes and endosymbionts drives function and development of symbiotic cells in mussel holobionts

The paper constructs a single-cell expression atlas of gill tissue in deep-sea mussels to study the molecular function and developmental trajectory of bacteriocytes and their interaction with endosymbionts.

Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament

This study reveals how cortactin stabilizes actin branches by interacting with activated Arp3 at the branch site, displacing other nucleation promoting factors.

H2O2 sulfenylates CHE linking local infection to establishment of systemic acquired resistance

The paper identifies H2O2-mediated sulfenylation of CHE as a mechanism for systemic acquired resistance in plants.

The membrane-cytoplasmic linker defines activity of FtsH proteases in Pseudomonas aeruginosa clone C

This study shows that the MC linker in PaFtsH2 affects its substrate processing efficiency, and modifying it can enhance its function in Pseudomonas aeruginosa.

Deciphering deep-sea chemosynthetic symbiosis by single-nucleus RNA-sequencing

This study uses single-nucleus RNA sequencing to create a cell atlas of deep-sea mussel gills, revealing cell types and their roles in supporting chemosynthetic symbiosis and environmental adaptation.

Genome Mining and Discovery of Imiditides, a Novel Family of RiPPs with a Class-defining Aspartimide Modification

This paper discovers a novel family of RiPPs called imiditides through genome mining, revealing 670 BGCs and demonstrating heterologous production of mNmaAM with a unique aspartimide modification.

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

This study designs synthetic oligomeric ligands to modulate FGFR signaling and shows their impact on vascular cell fate decisions.

Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells

This study shows that vaccinating with mycobacterial lipid-loaded nanoparticles induces persistent lipid antigen presence and memory T cell differentiation in mice.

An Unexpected Role of Neutrophils in Clearing Apoptotic Hepatocytes In Vivo

This study reveals that neutrophils, not macrophages, primarily clear apoptotic hepatocytes through a novel process called perforocytosis, and defects in this process contribute to autoimmune liver disease.

Ferroptosis is determined by chloride ions

This study identifies chloride ions as essential determinants of ferroptosis, showing that extracellular chloride levels influence lipid peroxidation and cell death.

Physical Activity Delays Obesity-Associated Pancreatic Ductal Adenocarcinoma in Mice and Decreases Inflammation

This study shows that physical activity delays obesity-associated pancreatic ductal adenocarcinoma in mice and reduces inflammation, with additional benefits when combined with a non-obesogenic diet.

Yeast and Mammalian Epsins Use Different Determinants for Localization and Function: Role of Clathrin/AP2/Ubiquitin Binding Motifs and Poly-Glutamine Stretches

This study compares yeast and mammalian Epsin localization and function, identifying differences in binding determinants and highlighting the role of poly-glutamine stretches.

Cooperative actin filament nucleation by the Arp2/3 complex and formins maintains the homeostatic cortical array in Arabidopsis epidermal cells

The paper investigates how Arp2/3 complex and formins cooperate to maintain the cortical actin array in Arabidopsis epidermal cells through single filament dynamics and genetic inhibition.

Nucleation and stability of branched versus linear Arp2/3-generated actin filaments

This study compares the nucleation and stability of branched versus linear actin filaments generated by Arp2/3 complex activation by VCA domains or SPIN90, revealing similar regulatory responses but distinct mechanical and temporal stability.

Single-cell RNA-sequencing analysis reveals the molecular mechanism of subchondral bone cell heterogeneity in the development of osteoarthritis

The paper uses single-cell RNA sequencing to identify novel cell subsets in subchondral bone of OA patients and elucidates their roles in disease progression.

Lysine acetylation regulates antibiotic resistance in Escherichia coli

This study identifies acetylation as a regulatory mechanism in antibiotic resistance in E. coli, showing it negatively affects metabolism but positively influences motility, with PykF acetylation playing a key role.

Bile Acid Restrained T Cell Activation Explains Cholestasis Aggravated Hepatitis B Virus Infection

This study shows that bile acids impair CD4+ T cell activation in cholestasis, worsening HBV infection outcomes by disrupting calcium signaling and metabolic reprogramming.