A. Xu

Estropausal gut microbiota transplant improves measures of ovarian function in adult mice

This study shows that transferring gut microbiota from young and estropausal mice improves ovarian function and fertility in adult mice.

Circular DNA vcDNA-S7 derived from segmented-dsRNA virus BmCPV attenuated viral infection through RNase H1

The paper identifies a novel antiviral mechanism where vcDNA-S7, derived from BmCPV, recruits RNase H1 to degrade viral RNA through heteroduplex formation, thereby suppressing viral replication.

Protein-protein interactions with G3BPs drive stress granule condensation and gene expression changes under cellular stress

The paper identifies key residues in G3BPs that drive stress granule formation and gene expression changes under cellular stress, with G3BP2B showing specific roles in ER stress.

WTAP, transcriptionally regulated by p65, promotes inflammation through m6A modification and phase separation

This study identifies WTAP as a p65-regulated m6A writer that promotes inflammation via phase separation and m6A modification, offering a therapeutic target for hyperinflammation.

Epigenetic Reshaping through Damage: Promoting Cell Fate Transition by BrdU and IdU Incorporation

The paper investigates how BrdU and IdU incorporation through DNA damage repair induces epigenetic changes that promote cell fate transition.

Single Cell Transcriptomes, Lineage, and Differentiation of Functional Airway Microfold Cells

This study identifies and characterizes airway Microfold (M) cells using single-cell transcriptomics, revealing their lineage, differentiation pathways, and functional role in antigen sampling via CR2-dependent endocytosis.

Major data analysis errors invalidate cancer microbiome findings

The paper re-analyzes a cancer microbiome study and identifies two major data and methodological errors that invalidate its findings and those of subsequent studies.

Putting a new spin on insect jumping performance using 3D modeling and computer simulations of spotted lanternfly nymphs

This paper uses high-speed video and 3D modeling to analyze the jumping and landing mechanics of spotted lanternfly nymphs, showing they control orientation via posture and drag torques for successful landings.

The spatially resolved tumor microenvironment predicts treatment outcome in relapsed/refractory Hodgkin lymphoma

The paper develops a prognostic model using spatially resolved tumor microenvironment features to predict treatment outcomes in relapsed/refractory Hodgkin lymphoma.

Kinesin-1 transports morphologically distinct intracellular virions during vaccinia infection

This study shows kinesin-1 transports two distinct vaccinia virion forms, IMV and IEV, with different speeds and motor complex numbers, and demonstrates the importance of kinesin-1 for viral spread.

Plant Metabolic Network: A multi-species resource of plant metabolic information

The paper updates the Plant Metabolic Network (PMN) with 126 genomes and tools for analyzing metabolism across species, revealing distinct metabolic groups and demonstrating applications in drought tolerance and cell-type specific metabolism.

FastTomo: A SerialEM Script for Collecting Electron Tomography Data

FastTomo is a SerialEM script that improves electron tomography data collection speed by minimizing off-target tracking shots and using proportional control.

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

Novel non-transposable-element regulation patterns of KZFP family reveal new drivers of its rapid evolution

This study identifies new regulatory patterns of KZFP family zinc fingers that drive their rapid evolution by binding non-transposable element regions and positively regulating gene expression.

Alteration of fecal microbial compositions and bacterial taxa in female osteoporotic patients

The paper compares fecal microbial compositions between female osteoporotic patients and healthy controls, identifying bacterial taxa associated with osteoporosis and demonstrating predictive power using a random forest model.

Trajectories from Snapshots: Integrated proteomic and metabolic single-cell assays reveal multiple independent adaptive responses to drug tolerance in a BRAF-mutant melanoma cell line

The paper uses integrated proteomic and metabolic single-cell assays to identify two distinct adaptive pathways in BRAF-mutant melanoma cells during drug treatment.

An Essential Role for Argonaute 2 in EGFR-KRAS Signaling in Pancreatic Cancer Development

This study shows AGO2 is required for pancreatic cancer progression but not initiation, with its role dependent on mutant KRAS and EGFR signaling.

Bclaf1 critically regulates the type I interferon response and is degraded by alphaherpesvirus US3

This study shows Bclaf1 is degraded by alphaherpesvirus US3 and is critical for type I interferon signaling and antiviral immunity.

Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control

The paper identifies RCAN2 as a regulator of cilia length that compensates for loss of giantin function in ciliogenesis.