Mutations of R882 in DNMT3A change flanking sequence preferences and cellular methylation patterns in AML
M. Emperle, S. Adam, S. Kunert, M. Dukatz, A. Baude, C. Plass, P. Rathert, P. Bashtrykov, A. Jeltsch
This study shows that DNMT3A R882 mutations alter flanking sequence preferences and methylation patterns, leading to hypermethylation and gene misregulation in AML.
bioRxiv · Aug 1, 2019Biochemistry