Author

P. Rathert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:human· 4 Research Focus:chromatin & epigenetic regulation· 3 Assay:ChIP-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Jeltsch· 2 shared P. Bashtrykov· 2 shared A. Baude· 1 shared A. Broehm· 1 shared A. C. Mueller· 1 shared A. G. Kouroukli· 1 shared A. Rendeiro· 1 shared A. Ringler· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

A. Jeltsch

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CRISPR gene and transcriptome engineering (CRISPRgate) improves loss-of-function genetic screening approaches

J. Stadager, C. Bernardini, L. Hartmann, H. May, J. Wiepcke, M. Kuban, Z. Najafova, S. A. Johnsen, S. Legewie, F. R. Traube, J. Jude, P. Rathert

CRISPRgate improves loss-of-function screening by combining CRISPRko and CRISPRi to enhance gene repression and reduce noise in genetic studies.

bioRxiv · May 14, 2024Biochemistry

SETDB1 activity is globally directed by H3K14 acetylation via its Triple Tudor Domain

T. T. Chandrasekaran, M. Choudalakis, A. Broehm, S. Weirich, A. G. Kouroukli, O. Ammerpohl, P. Rathert, P. Bashtrykov, A. Jeltsch

This study shows that H3K14 acetylation directs SETDB1 activity via its Triple Tudor Domain, enabling H3K9 methylation and heterochromatin formation.

bioRxiv · Apr 22, 2024Biochemistry

Mutations of R882 in DNMT3A change flanking sequence preferences and cellular methylation patterns in AML

M. Emperle, S. Adam, S. Kunert, M. Dukatz, A. Baude, C. Plass, P. Rathert, P. Bashtrykov, A. Jeltsch

This study shows that DNMT3A R882 mutations alter flanking sequence preferences and methylation patterns, leading to hypermethylation and gene misregulation in AML.

bioRxiv · Aug 1, 2019Biochemistry

MTHFD1 is a genetic interactor of BRD4 and links folate metabolism to transcriptional regulation

S. Sdelci, A. Rendeiro, P. Rathert, G. Hofstaetter, A. Ringler, H. P. Moll, W. You, K. Klavins, B. Guertl, M. Farlik, S. Schick, F. Klepsch, M. Oldach, P. Buphamalai, F. Schischlik, , S. Kubicek

This study identifies MTHFD1 as a genetic and physical interactor of BRD4, linking folate metabolism to transcriptional regulation and showing synergistic effects on cancer cell viability.

bioRxiv · Oct 10, 2018Cancer Biology