P. Bashtrykov

SETDB1 activity is globally directed by H3K14 acetylation via its Triple Tudor Domain

This study shows that H3K14 acetylation directs SETDB1 activity via its Triple Tudor Domain, enabling H3K9 methylation and heterochromatin formation.

Mutations of R882 in DNMT3A change flanking sequence preferences and cellular methylation patterns in AML

This study shows that DNMT3A R882 mutations alter flanking sequence preferences and methylation patterns, leading to hypermethylation and gene misregulation in AML.