C. Plass

SRSF2 transcriptional function maintains genome integrity during cell division

This study shows that SRSF2 mutations cause DNA damage and cell cycle arrest, highlighting its role in transcription regulation during cell division.

Oncogenic RAS-Pathway Activation Drives Oncofetal Reprogramming and Creates Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia

This study identifies oncofetal reprogramming in juvenile myelomonocytic leukemia, linking RAS-pathway activation to fetal gene expression and revealing CD52 as a therapeutic target.

Epigenetic deregulation of IFN and WNT pathways in AT2 cells impairs alveolar regeneration (in COPD)

This study identifies epigenetic changes in AT2 cells from COPD patients that disrupt IFN and WNT pathways, impairing lung regeneration.

Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)

The paper shows MNX1 overexpression in t(7;12)(q36;p13) AML is due to enhancer hijacking, not oncofusion, and is common in pediatric cases.

Multidimensional Characterization of Soft-Tissue Sarcomas with FUS-TFCP2 or EWSR1-TFCP2 Fusions

This study characterizes soft-tissue sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions through multi-omics analyses and functional studies, identifying therapeutic targets and mechanisms of disease.

Aberrant MNX1 Expression Associated with t(7;12)(q36;p13) Pediatric Acute Myeloid 1 Leukemia Induces the Disease Through Altering Histone Methylation

This study identifies MNX1 as a driver of t(7;12)(q36;p13) pediatric AML by altering histone methylation and shows that targeting MNX1 can prevent leukemia development.

High-resolution epigenetic profiling identifies novel regulators of COPD in human lung fibroblasts

This study identifies novel epigenetic and transcriptomic regulators of COPD in human lung fibroblasts across disease stages.

MEOX2 homeobox gene promotes growth of malignant gliomas

This study identifies MEOX2 as an oncogenic transcription factor in glioblastoma, showing it promotes tumor growth through ERK signaling and cooperates with p53 and PTEN loss.

Diverse routes of Club cell evolution in lung adenocarcinoma

This study identifies Club cells as a major cell-of-origin for lung adenocarcinoma, revealing two evolutionary trajectories similar to lung regeneration and tumor-specific epigenetic changes.

Versatile workflow for cell type resolved transcriptional and epigenetic profiles from cryopreserved human lung.

This paper develops a cryopreservation workflow for human lung tissue that maintains cell viability and omics profiles, enabling single-cell and bulk sequencing for studying lung diseases.

Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL

This study introduces Methyl-COOM, a method to identify cell-of-origin and CLL-specific epigenetic aberrations by analyzing DNA methylation patterns.

Activation-induced deaminase is critical for the establishment of DNA methylation patterns prior to the germinal center reaction

This study investigates AID's role in DNA methylation defects in HIGM2 B cells, finding that AID is not directly involved in active demethylation but TET enzymes are, and that methylation defects are linked to premature BCR activation.

Mutations of R882 in DNMT3A change flanking sequence preferences and cellular methylation patterns in AML

This study shows that DNMT3A R882 mutations alter flanking sequence preferences and methylation patterns, leading to hypermethylation and gene misregulation in AML.

Random forest-based modelling to detect biomarkers for prostate cancer progression

This study uses a random forest model to identify DNA methylation biomarkers for prostate cancer progression, finding ZIC2 expression loss as an independent prognostic marker.