Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy
S. L. Brody, J. Pan, T. Huang, J. Xu, H. Huang, J. Koenitzer, S. K. Brennan, R. Nanjundappa, T. G. Saba, A. Berical, F. J. Hawkins, X. Wang, R. Zhang, M. R. Mahjoub, A. Horani, S. K. Dutcher
The paper identifies cellular defects beyond motility loss in ciliopathies caused by CCDC39/CCDC40 variants, showing proteostasis disruption and cell fate switching.
bioRxiv · Mar 20, 2024 · PreprintCell Biology