J. Pan

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

Structural and functional analysis of the Nipah virus polymerase complex

This study determines the cryo-EM structure of the Nipah virus polymerase complex and identifies key domains critical for replication and transcription.

Bivariate multilevel meta-analysis of log response ratio and standardized mean difference for robust and reproducible environmental and biological sciences

This paper introduces a bivariate multilevel meta-analysis method for log response ratio and standardized mean difference to improve reproducibility and reduce false positives in environmental and biological meta-analyses.

A Fast and Low-Cost Approach for Binding Mode Validation of AI-Designed Therapeutics

The paper introduces HDX FineMapping, a method that achieves full sequence coverage and epitope characterization for AI-designed therapeutics without requiring mutations or crystallization.

Circular DNA vcDNA-S7 derived from segmented-dsRNA virus BmCPV attenuated viral infection through RNase H1

The paper identifies a novel antiviral mechanism where vcDNA-S7, derived from BmCPV, recruits RNase H1 to degrade viral RNA through heteroduplex formation, thereby suppressing viral replication.

Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy

The paper identifies cellular defects beyond motility loss in ciliopathies caused by CCDC39/CCDC40 variants, showing proteostasis disruption and cell fate switching.

Identification and classification of the genomes of novel Microviruses in a poultry slaughterhouse

This study identifies 98 novel microvirus genomes from a poultry slaughterhouse, classifies them into 6 new subfamilies and 3 higher-level units, and expands their known host range.

A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

This study identifies tonic activation of the cGAS-STING and IFN pathways in ACE2-positive airway cells as a factor limiting SARS-CoV-2 replication.

Comprehensive Multi-Omic Analysis Reveals Distinct Molecular Features in Early and Advanced Stages of Hepatocellular Carcinoma

This study uses multi-omic analyses to identify molecular features and biomarkers in early and advanced hepatocellular carcinoma stages.

Structural basis for VLDLR recognition by eastern equine encephalitis virus

This study determines the structures of EEEV and SFV spike glycoproteins bound to VLDLR, revealing distinct binding modes that explain how different alphaviruses use the same receptor.

Melanophilin mediates the association of myosin-5a with melanosome via three distinct interactions

This study identifies a third interaction between Myo5a and Mlph, involving the exon-G region of Myo5a and Mlph-ABD, which is required for melanosome association.

Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid Availability

This study reveals spatially and functionally distinct mTORC1 entities that regulate cellular responses to amino acid availability through lysosomal and non-lysosomal mechanisms.

A role for the ATP-dependent DNA ligase Lig E of Neisseria gonorrhoeae in biofilm formation

This study shows that Lig E in Neisseria gonorrhoeae is non-essential for DNA repair but plays a role in biofilm formation and extracellular DNA joining.

Real-Time Spatiotemporal Measurement of Extracellular Signaling Molecules Using an Aptamer Switch-Conjugated Hydrogel Matrix

The paper develops a hydrogel-based sensor to measure extracellular signaling molecules in real-time and demonstrates its use for cAMP in Dictyostelium discoideum.

A rapid ELISA platform with no sample preparation requirement

This paper introduces a rapid ELISA platform that requires no sample preparation, enabling quick quantification of protein biomarkers in blood samples.

Clathrin Light Chains are essential in negative regulation of cell death and immunity in Arabidopsis through interacting with autophagy pathway

This study shows that clathrin light chains in Arabidopsis interact with autophagy proteins, impairing autophagy and leading to accelerated senescence and immune activation.

Inhibition of type III secretion system induced leukotriene B4 production by Yersinia pestis: A mechanism for early immune evasion

This paper identifies how Yersinia pestis inhibits leukotriene B4 production, a key inflammatory lipid, to evade the host immune response during plague.

An Antibody-Based Molecular Switch for Continuous Biosensing

This paper introduces an antibody-based molecular switch for continuous biosensing of biomarkers without sample preparation, demonstrating real-time detection of digoxigenin and cortisol with adjustable sensitivity.

E2F1 Mediates SOX17 Deficiency-Induced Pulmonary Hypertension

This study shows that SOX17 deficiency in endothelial cells causes pulmonary hypertension via E2F1 signaling, suggesting E2F1 as a therapeutic target in PAH.

The effect of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes

This study investigates the effects of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes using mouse models, revealing allele-specific and tissue-specific molecular requirements for cilia motor assembly.

The prospect of universal coronavirus immunity: a characterization of reciprocal and non-reciprocal T cell responses against SARS-CoV2 and common human coronaviruses

The paper investigates T cell cross-reactivity between SARS-CoV2 and common human coronaviruses, finding broad immunity in survivors and reduced omicron recognition in vaccinated individuals.

Japanese Encephalitis Virus NS1 Protein regulates the expression and distribution of TIM-1 to promote viral infection

This study shows that JEV NS1 protein increases TIM-1 expression and shifts its distribution to the cytoplasm, enhancing viral infection by reducing TIM-1-mediated restriction.

Immunogenic fusion proteins induce neutralizing SARS-CoV-2 antibodies in the serum and milk of sheep

This study shows that immunogenic fusion proteins induce neutralizing SARS-CoV-2 antibodies in sheep serum and milk, with cross-neutralizing activity against variants.

TMEM100, a Lung-Specific Endothelium Gene

This study identifies Tmem100 as a lung-specific endothelial gene through single-cell RNA-sequencing analysis.

Environmental Stability of Enveloped Viruses is Impacted by the Initial Volume and Evaporation Kinetics of Droplets

This study examines how droplet volume and humidity affect the environmental stability of enveloped viruses, finding that virus decay is more similar at higher humidity and in smaller droplets.

An NKX-COUP-TFII genomic code for mucosal vascular addressins and organ morphogenesis

The paper identifies a genomic code involving NKX-COUP-TFII elements that regulate mucosal vascular addressin expression and organ morphogenesis.

Notch signaling in tumor vasculature programs cancer-associated fibroblasts to suppress anti-tumor immunity

This study shows that Notch signaling in tumor endothelial cells suppresses CAFs' pro-inflammatory functions, limiting T cell recruitment and suggesting targeting EC-CAF interactions to enhance anti-tumor immunity.

Activation of retinoic acid receptor reduces metastatic prostate cancer bone lesions through blocking endothelial-to-osteoblast transition

Proteomic Characterization of Isolated Arabidopsis Clathrin-Coated Vesicles Reveals Evolutionarily Conserved and Plant Specific Components

The paper characterizes the proteome of Arabidopsis clathrin-coated vesicles, identifying conserved and plant-specific components involved in clathrin-mediated trafficking.

Isolation, identification and molecular characterization of Aeromonas spp. from farmed loach (Misgurnus anguillicaudatus)

This study identifies and characterizes Aeromonas species in farmed loaches from China, finding high prevalence of A. veronii and resistance to multiple antibiotics.