macroH2A2 shapes chromatin accessibility at enhancer elements in glioblastoma to modulate a targetable self-renewal epigenetic network
A. Nikolic, A. Bobyn, F. Maule, K. Ellestad, X. Lun, M. Johnston, C. Gafuik, F. Zemp, S. Paik, N. Ninkovic, S. Marhon, P. Mehdipour, Y. Shen, D. Berger, D. Brownsey, , M. Gallo
This study identifies macroH2A2 as a regulator of chromatin accessibility at enhancers in glioblastoma, showing that inhibiting Menin increases macroH2A2 and represses self-renewal.
bioRxiv · Feb 23, 2021 · PreprintCancer Biology