Author

A. Nikolic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6

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Organism:human· 6 Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:ATAC-seq· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

M. Gallo· 6 shared F. J. Coutinho· 3 shared F. M. Cavalli· 3 shared K. Ellestad· 3 shared M. D. Taylor· 3 shared M. M. Kushida· 3 shared A. J. Mungall· 2 shared J. A. Chan· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersCancer Biology

M. Gallo

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6 papers

Recent·Most cited

Single cell spatial analysis identifies regulators of brain tumor initiating cells

R. Mirzaei, C. D'Mello, M. Liu, A. Nikolic, M. Kumar, F. Visser, P. Bose, M. Gallo, V. W. Yong

The paper identifies biglycan as a regulator of brain tumor initiating cells through spatial transcriptomics and single-cell ATAC-seq, showing its role in Wnt/β-catenin pathway activation and tumor growth.

bioRxiv · Sep 13, 2022Cancer Biology

macroH2A2 shapes chromatin accessibility at enhancer elements in glioblastoma to modulate a targetable self-renewal epigenetic network

A. Nikolic, A. Bobyn, F. Maule, K. Ellestad, X. Lun, M. Johnston, C. Gafuik, F. Zemp, S. Paik, N. Ninkovic, S. Marhon, P. Mehdipour, Y. Shen, D. Berger, D. Brownsey, , M. Gallo

This study identifies macroH2A2 as a regulator of chromatin accessibility at enhancers in glioblastoma, showing that inhibiting Menin increases macroH2A2 and represses self-renewal.

bioRxiv · Feb 23, 2021 · PreprintCancer Biology

Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer

Y. Inoue, A. Nikolic, D. Farnsworth, A. Liu, M. Ladanyi, R. Somwar, M. Gallo, W. Lockwood

This study identifies the ERK-CBP/p300-ETS axis as promoting lineage transformation between neuroendocrine and non-neuroendocrine lung cancer subtypes through chromatin rewiring.

bioRxiv · Nov 12, 2020Cancer Biology

Single-cell chromatin accessibility in glioblastoma delineates cancer stem cell heterogeneity predictive of survival

P. Guilhamon, M. M. Kushida, A. Nikolic, D. Singhal, G. MacLeod, S. A. M. Tonekaboni, F. M. Cavalli, C. Arlidge, N. Rajakulendran, N. Rastegar, X. Hao, R. Hassam, L. J. Smith, H. Whetstone, F. J. Coutinho, , M. Lupien

The paper uses single-cell chromatin accessibility to identify distinct glioblastoma stem cell states predictive of patient survival.

bioRxiv · Mar 13, 2020 · PreprintCancer Biology

High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma

M. J. Johnston, A. Nikolic, N. Ninkovic, P. Guilhamon, F. M. Cavalli, S. Seaman, F. J. Zemp, J. Lee, A. Abdelkareem, K. Ellestad, A. Murison, M. M. Kushida, F. J. Coutinho, Y. Ma, A. J. Mungall, , M. Gallo

This study uses high-resolution 3D genome maps to identify CD276 as a therapeutic target in glioblastoma stem cells, showing it can suppress self-renewal.

bioRxiv · Oct 13, 2018Cancer Biology

Subclonal architecture, evolutionary trajectories and patterns of inheritance of germline variants in pediatric glioblastoma

M. Hoffman, A. H. Gillmor, D. J. Kunz, M. J. Johnston, A. Nikolic, K. Karta, J. King, K. Ellestad, N. H. Dang, F. M. Cavalli, M. M. Kushida, F. J. Coutinho, B. Luu, Y. Ma, A. J. Mungall, , M. Gallo

This study examines genetic heterogeneity and evolutionary patterns in pediatric glioblastoma using whole-genome sequencing of germline-tumor pairs, revealing subclonal architecture and complex inheritance mechanisms.

bioRxiv · Oct 12, 2018Cancer Biology