Author

A. Bosco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

P. G. Holt· 4 shared D. H. Strickland· 3 shared A. C. Jones· 2 shared M. Serralha· 2 shared A. N. Larcombe· 1 shared A. Saxena· 1 shared B. J. Holt· 1 shared C. A. Rinaldi· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersImmunology

P. G. Holt

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Single cell transcriptomics reveals cell type specific features of developmentally regulated responses to lipopolysaccharide between birth and 5 years.

J. F. Read, M. Serralha, J. Armitage, M. M. Iqbal, M. N. Cruickshank, A. Saxena, D. H. Strickland, J. Waithman, P. G. Holt, A. Bosco

This study uses single cell RNA-sequencing to compare the transcriptional responses to LPS in cord blood and 5-year-old peripheral blood mononuclear cells, revealing developmental changes in immune cell signaling and communication.

Frontiers in Immunology · Oct 17, 2023Peer-reviewedImmunology

Geldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic mesothelioma

M. L. Orozco Morales, C. A. Rinaldi, E. de Jong, S. M. Lansley, Y. C. G. Lee, R. M. Zemek, A. Bosco, R. A. Lake, W. J. Lesterhuis

The paper evaluates geldanamycin's anti-cancer effects in mesothelioma models, finding it inhibits tumor cells in vitro but not in vivo.

bioRxiv · Aug 29, 2022Cancer Biology

Early-life respiratory viral infection results in impairment of adult lung function

L. Harb, P. G. Holt, D. H. Strickland, D. Martino, A. N. Larcombe, A. Bosco

This study establishes a mouse model of early-life respiratory viral infection that leads to adult lung function impairment, showing sex-dependent effects and pathogen-specific outcomes.

bioRxiv · Sep 20, 2021 · PreprintImmunology

Transplacental innate immune training via maternal microbial exposure: a central role for the XBP1-ERN1 axis in programming dendritic cell precursors

K. T. Mincham, A. C. Jones, M. Bodinier, N. M. Scott, J.-F. Lauzon-Joset, P. A. Stumbles, A. Bosco, P. G. Holt, D. H. Strickland

This study identifies the XBP1-ERN1 axis as critical for maternal OM-85-induced immune training in fetal dendritic cell precursors, enhancing postnatal resistance to airway inflammation.

bioRxiv · May 15, 2020Immunology

Rewiring of Th-memory-associated gene co-expression networks underlie immunotherapy-induced changes in symptom expression in mite-sensitised atopics

A. C. Jones, D. Anderson, N. M. Troy, D. Mallon, R. Hartmann, M. Serralha, B. J. Holt, A. Bosco, P. G. Holt

This study shows that immunotherapy induces rewiring of gene co-expression networks in Th-memory responses, leading to stable symptom control through integration of Th2, FOXP3/IL2, inflammation, and Type1-IFN signaling modules.

bioRxiv · Oct 31, 2019 · PreprintImmunology