P. G. Holt

This study uses single cell RNA-sequencing to compare the transcriptional responses to LPS in cord blood and 5-year-old peripheral blood mononuclear cells, revealing developmental changes in immune cell signaling and communication.

The paper identifies lung hematopoietic progenitors that change with age and respond to Influenza A infection by altering progenitor populations and immunological homeostasis.

The paper shows that a maternal low-fibre diet disrupts infant immune development, increasing susceptibility to respiratory infections and asthma, and that propionate-producing bacteria can reverse this effect.

This study establishes a mouse model of early-life respiratory viral infection that leads to adult lung function impairment, showing sex-dependent effects and pathogen-specific outcomes.

Maternal treatment with OM-85 during pregnancy enhances neonatal resistance to respiratory viral infection by accelerating immune maturation and improving lung immune responses.

This study identifies the XBP1-ERN1 axis as critical for maternal OM-85-induced immune training in fetal dendritic cell precursors, enhancing postnatal resistance to airway inflammation.

This study shows that immunotherapy induces rewiring of gene co-expression networks in Th-memory responses, leading to stable symptom control through integration of Th2, FOXP3/IL2, inflammation, and Type1-IFN signaling modules.

The paper identifies gene expression quantitative trait loci (eQTLs) in neonatal immune cells and links them to autoimmune and allergic disease risk through colocalisation and Mendelian randomisation.