Author

M. Serralha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Bosco· 2 shared M. M. Iqbal· 2 shared P. G. Holt· 2 shared A. C. Jones· 1 shared A. Saxena· 1 shared B. J. Holt· 1 shared D. Anderson· 1 shared D. H. Strickland· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

A. Bosco

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Author profile →

3 papers

Recent·Most cited

Single cell transcriptomics reveals cell type specific features of developmentally regulated responses to lipopolysaccharide between birth and 5 years.

J. F. Read, M. Serralha, J. Armitage, M. M. Iqbal, M. N. Cruickshank, A. Saxena, D. H. Strickland, J. Waithman, P. G. Holt, A. Bosco

This study uses single cell RNA-sequencing to compare the transcriptional responses to LPS in cord blood and 5-year-old peripheral blood mononuclear cells, revealing developmental changes in immune cell signaling and communication.

Frontiers in Immunology · Oct 17, 2023Peer-reviewedImmunology

Mapping the landscape of chromatin dynamics during naïve CD4+ T-cell activation.

M. M. Iqbal, M. Serralha, P. Kaur, D. Martino

This study uses omni ATAC-seq to map chromatin changes in naive CD4+ T-cells during activation, identifying enhancer regions and transcriptional signatures associated with T-cell responses.

bioRxiv · Jul 30, 2020Immunology

Rewiring of Th-memory-associated gene co-expression networks underlie immunotherapy-induced changes in symptom expression in mite-sensitised atopics

A. C. Jones, D. Anderson, N. M. Troy, D. Mallon, R. Hartmann, M. Serralha, B. J. Holt, A. Bosco, P. G. Holt

This study shows that immunotherapy induces rewiring of gene co-expression networks in Th-memory responses, leading to stable symptom control through integration of Th2, FOXP3/IL2, inflammation, and Type1-IFN signaling modules.

bioRxiv · Oct 31, 2019 · PreprintImmunology