Interleukin-6 Drives Key Pathologic Outcomes in Experimental Acetaminophen-induced Liver Failure
K. Roth, J. Strickland, R. Gonzalez-Pons, A. Pant, T.-C. Yen, R. Freeborn, R. Kennedy, B. Bhushan, A. Boss, C. E. Rockwell, A. M. Dorrance, U. Apte, J. P. Luyendyk, B. L. Copple
This study shows that excessive IL-6 in acetaminophen-induced liver failure causes immune suppression, reduced cerebral blood flow, and increased mortality in mice.
bioRxiv · Nov 15, 2021 · PreprintPathology