Author

K. Roth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Bhatt· 1 shared A. Boss· 1 shared A. Burchert· 1 shared A. Bysice· 1 shared A. M. Dorrance· 1 shared A. M. Hartmann· 1 shared A. Neubauer· 1 shared A. Nist· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. Bhatt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pannexin 1 and Pannexin 3 differentially regulate the tumorigenic properties of cutaneous squamous cell carcinoma

B. L. O'Donnell, D. Johnston, A. Bhatt, Z. Kardan, D. Stefan, A. Bysice, S. Sayedyahossein, L. Dagnino, M. Cecchini, S. K. Loganathan, K. Roth, S. Penuela

This study investigates the differential roles of PANX1 and PANX3 in cutaneous squamous cell carcinoma, finding PANX1 promotes tumorigenesis while PANX3 suppresses it.

bioRxiv · Apr 8, 2024 · PreprintCancer Biology

IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

D. Das Gupta, C. Paul, N. Samel, M. Bieringer, D. Staudenraus, F. Marini, H. Raifer, L. Menke, L. Hansal, B. Camara, E. Roth, P. Daum, M. Wanzel, M. Mernberger, A. Nist, , M. Lohoff

This study shows IRF4 deficiency leads to B cell leukemia via Jak3 mutations that increase IL-7 sensitivity, and JAK inhibition improves survival in a mouse model.

bioRxiv · Feb 16, 2022 · PreprintCancer Biology

Temporal control of the integrated stress response by a stochastic molecular switch

P. Klein, S. M. Kallenberger, H. Roth, K. Roth, T. B. N. Ly-Hartig, V. Magg, J. Ales, S. Rastgou Talemi, Y. Qiang, S. Wolf, O. Oleksiuk, R. Kurilov, B. Di Ventura, R. Bartenschlager, R. Eils, , A. Ruggieri

The paper identifies a stochastic molecular switch controlling the integrated stress response through cooperative activation of PKR, ultrasensitive eIF2 phosphorylation, and negative feedback via GADD34.

bioRxiv · Jan 1, 2022Cell Biology

Interleukin-6 Drives Key Pathologic Outcomes in Experimental Acetaminophen-induced Liver Failure

K. Roth, J. Strickland, R. Gonzalez-Pons, A. Pant, T.-C. Yen, R. Freeborn, R. Kennedy, B. Bhushan, A. Boss, C. E. Rockwell, A. M. Dorrance, U. Apte, J. P. Luyendyk, B. L. Copple

This study shows that excessive IL-6 in acetaminophen-induced liver failure causes immune suppression, reduced cerebral blood flow, and increased mortality in mice.

bioRxiv · Nov 15, 2021 · PreprintPathology