U. Apte

Multi-Omics after O-GlcNAc Alteration Identifies Cellular Processes Working Synergistically to Promote Aneuploidy

The paper uses multi-omics analysis to show OGT regulates aneuploidy by fine-tuning multiple cellular pathways through O-GlcNAcylation.

Role of HNF4alpha-cMyc Interaction in CDE-diet Induced Liver Injury and Regeneration

This study examines the role of HNF4-cMyc interaction in liver injury and regeneration using a CDE diet model, finding that HNF4 deletion increases injury while cMyc deletion decreases it, with combined deletion leading to a unique HPC activation phenotype.

Regulation of Hepatic Xenosensor Function by HNF4alpha

This study shows that HNF4alpha is essential for the function of CAR, PXR, and PPAR but not AhR in hepatic xenosensor activation.

The Essential Role of O-GlcNAcylation in Hepatic Differentiation

This study shows that O-GlcNAcylation is essential for hepatocyte differentiation and its loss promotes liver fibrosis and hepatocellular carcinoma.

Interference with the HNF4-dependent gene regulatory network diminishes ER stress in hepatocytes

The paper identifies HNF4-dependent genes suppressed by ER stress in the liver and shows that HNF4 deletion reduces UPR activation and ER stress.

Identifying Human Specific Adverse Outcome Pathways of Per- and Polyfluoroalkyl Substances Using Liver-Chimeric Humanized Mice

This study uses liver-chimeric humanized mice to identify human-specific adverse hepatic effects of PFAS, finding NR1D1 inhibition as a common molecular mechanism.

Global Transcriptomics of Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease using PCK rats

This study uses RNA-Seq on PCK rat liver samples to identify differentially expressed genes and pathways involved in CHF/ARPKD pathogenesis.

Interleukin-6 Drives Key Pathologic Outcomes in Experimental Acetaminophen-induced Liver Failure

This study shows that excessive IL-6 in acetaminophen-induced liver failure causes immune suppression, reduced cerebral blood flow, and increased mortality in mice.

Regulation of Liver Regeneration by hepatocyte O-GlcNAcylation in mice

This study shows that O-GlcNAcylation in hepatocytes is essential for proper liver regeneration, with its loss leading to uncontrolled proliferation and tumor formation.

Mutational mimics of allosteric effectors: a genome editing design to validate allosteric drug targets

The paper identifies point mutations that mimic allosteric effectors in human liver pyruvate kinase to validate potential drug targets for treating diabetes.

Hepatocyte-Specific Hepatocyte Nuclear Factor 4 alpha (HNF4α) Deletion Decreases Resting Energy Expenditure By Disrupting Lipid and Carbohydrate Homeostasis

This study shows that deleting HNF4α in hepatocytes reduces resting energy expenditure by disrupting lipid and carbohydrate homeostasis in mice.

Hepatocyte Nuclear Factor 4 alpha (HNF4α) Activation is Essential for Termination of Liver Regeneration

This study shows that HNF4α reexpression after liver injury is critical for hepatocytes to exit the cell cycle and resume function during liver regeneration.

Global analysis of plasma lipids identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis

This study identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis, showing that cold exposure increases plasma acylcarnitine levels through hepatic HNF4 activation and that carnitine supplementation improves thermogenic response in aged mice.