Peripheral blood mononuclear cells preferentially activate 11-oxygenated androgens
L. Schiffer, A. Bossey, A. E. Taylor, I. Akerman, D. Scheel-Toellner, K.-H. Storbeck, W. Arlt
The paper shows human PBMCs preferentially activate 11-oxygenated androgens over classic androgens, with AKR1C3 in natural killer cells driving this conversion, and delayed sample processing increases serum 11KT levels.
bioRxiv · Sep 8, 2020Biochemistry