Author

I. Akerman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:human· 4 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Assay:proteomics· 2

Frequent Co-Authors

D. J. Hodson· 3 shared D. Nasteska· 3 shared D. A. Tennant· 2 shared F. Cuozzo· 2 shared G. G. Lavery· 2 shared K. Viloria· 2 shared A. Bossey· 1 shared A. Boufersaoui· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersPhysiology

D. J. Hodson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A heterozygous CEBPA mutation disrupting the bZIP domain causes MDS disease progression

R. Almaghrabi, Y. Alyayhawi, P. Keane, C. R. J. Ward, R. Bayley, C. Sargas, P. Menendez, G. J. Murphy, T. Sobahy, M. A. Baghdadi, A. F. Flemban, S. Kabrah, I. Akerman, M. Raghavan, E. Barragan, , P. Garcia

This study shows a heterozygous CEBPA mutation in the bZIP domain causes MDS progression by altering chromatin structure and clonal composition, using patient-derived iPSCs.

bioRxiv · Jul 24, 2023Cancer Biology

High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cells

F. Cuozzo, K. Viloria, A. H. Shilleh, D. Nasteska, C. Frazer-Morris, Z. Jiao, A. Boufersaoui, B. Marzullo, H. R. Smith, C. Bonner, J. Kerr-Conte, F. Pattou, R. Nano, L. Piemonti, P. R. Johnson, , D. J. Hodson

The paper uses metabolic tracing and imaging to show that human pancreatic β cells produce lactate, regulated by LDHB expression, which affects Ca2+ spiking without altering ATP/ADP levels.

bioRxiv · Dec 21, 2022 · PreprintPhysiology

Peripheral blood mononuclear cells preferentially activate 11-oxygenated androgens

L. Schiffer, A. Bossey, A. E. Taylor, I. Akerman, D. Scheel-Toellner, K.-H. Storbeck, W. Arlt

The paper shows human PBMCs preferentially activate 11-oxygenated androgens over classic androgens, with AKR1C3 in natural killer cells driving this conversion, and delayed sample processing increases serum 11KT levels.

bioRxiv · Sep 8, 2020Biochemistry

The prolyl hydroxylase PHD3 maintains β-cell glucose metabolism during fatty acid excess

D. Nasteska, F. Cuozzo, A. Thakker, R. Bany Bakar, R. Westbrook, I. Akerman, J. Cantley, D. A. Tennant, D. J. Hodson

This paper shows that PHD3 deletion in beta-cells impairs glucose homeostasis under high fat diet by altering fuel utilization and metabolic pathways.

bioRxiv · Apr 30, 2020 · PreprintPhysiology

Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion

K. Viloria, D. Nasteska, L. J. B. Briant, S. Helsing, D. Larner, N. H. F. Fine, F. B. Ashford, G. da Silva Xavier, M. Jimenez Ramos, J. E. Manning Fox, P. E. MacDonald, I. Akerman, G. G. Lavery, C. Flaxman, N. G. Morgan, , D. J. Hodson

This study shows that vitamin D-binding protein (DBP) is essential for maintaining β-cell function and glucagon secretion, with reduced DBP expression observed in late-onset type 1 diabetes.

bioRxiv · Dec 19, 2019 · PreprintPhysiology