Author

W. Arlt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:proteomics· 2

Frequent Co-Authors

A. E. Taylor· 7 shared L. C. Gilligan· 3 shared L. Schiffer· 3 shared K.-H. Storbeck· 2 shared A. Bossey· 1 shared A. Csala· 1 shared A. Freeman· 1 shared A. Groll· 1 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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7 shared papersPhysiology

A. E. Taylor

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Characterization of a Biochemical Mouse Model of Primary Aldosteronism for Thermal Therapies

S. A. Keck, N. Mullen, A. E. Taylor, L. C. Gliligan, M. Pyle, T. B. Shrestha, J. Sebek, M. A. Highland, R. Challapalli, W. Arlt, S. H. Bossmann, M. C. Dennedy, P. Prakash, M. T. Basel

The paper develops a mouse model of aldosterone-producing adenoma to test thermal ablation therapies, showing reduced aldosterone production after treatment.

bioRxiv · May 7, 2024 · PreprintCancer Biology

A cardiotonic steroid multiplex method using ultra-high-performance liquid chromatography-tandem mass spectrometry

L. C. Gilligan, D. Alamrani, D. Fobian, D. Kotecha, P. Kirchhof, W. Arlt, A. E. Taylor, D. Pavlovic

The paper develops a UHPLC-MS/MS method to quantify eleven cardiotonic steroids in serum and plasma.

bioRxiv · Oct 7, 2023 · PreprintPhysiology

Gonadal androgens are associated with decreased type I interferon production by pDCs and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents

O. L. Sampson, C. Jay, E. Adland, A. Csala, N. Lim, S. M. Ebbrecht, L. C. Gilligan, A. E. Taylor, S. S. George, S. Longet, L. C. Jones, E. Barnes, J. Frater, P. Klenerman, S. Dunachie, , P. Goulder

The paper investigates how gonadal androgens affect type I interferon production by pDCs and IgG titres to BNT162b2 in adolescents co-vaccinated with LAIV.

bioRxiv · Aug 1, 2023 · PreprintImmunology

Autophagy maintains the homeostatic environment in the male reproductive accessory organs playing a key role in fertility

A. Jaulim, L. D. Cassidy, A. R. J. Young, A. S. L. Chan, A. Y. Warren, A. E. Taylor, W. Arlt, G. Lan, M. L. Blayney, O. Davidson, C. L. R. Barratt, S. Pacey, M. Narita

This study shows that autophagy is essential for maintaining the function of male reproductive accessory organs, and its inhibition leads to subfertility, with recovery upon autophagy restoration.

bioRxiv · Jul 21, 2023 · PreprintCell Biology

Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 drives concurrent 11-oxygenated androgen excess

L. Schiffer, I. Oestlund, J. Snoep, L. C. Gilligan, A. E. Taylor, A. J. Sinclair, R. Singhal, A. Freeman, R. Ajjan, A. Tiganescu, W. Arlt, K.-H. Storbeck

This study shows that inhibiting HSD11B1 increases 11-ketotestosterone levels in adipose tissue and circulation, potentially offsetting benefits of reduced glucocorticoid activation in women.

bioRxiv · Jun 5, 2023Biochemistry

Peripheral blood mononuclear cells preferentially activate 11-oxygenated androgens

L. Schiffer, A. Bossey, A. E. Taylor, I. Akerman, D. Scheel-Toellner, K.-H. Storbeck, W. Arlt

The paper shows human PBMCs preferentially activate 11-oxygenated androgens over classic androgens, with AKR1C3 in natural killer cells driving this conversion, and delayed sample processing increases serum 11KT levels.

bioRxiv · Sep 8, 2020Biochemistry

Testosterone enhances GLP-1 efficacy at the plasma membrane and endosomes to augment insulin secretion in male pancreatic β cells

W. Xu, F. Ashford, S. Bitsi, L. Schiffer, F. Qadir, W. Arlt, A. Tomas, D. Hodson, F. Mauvais-Jarvis

This paper shows testosterone enhances GLP-1's ability to increase insulin secretion in male β cells by boosting cAMP production at the plasma membrane and endosomes.

bioRxiv · May 12, 2020 · PreprintPhysiology

Mapping the steroid response to major trauma from injury to recovery: a prospective cohort study

M. A. Foster, A. E. Taylor, N. E. Hill, C. Bentley, J. Bishop, F. Shaheen, L. Gilligan, J. F. Bion, J. L. Fallowfield, D. R. Woods, I. Bancos, M. Midwinter, J. Lord, W. Arlt

This study tracks steroid hormone changes and recovery in male trauma survivors, finding acute and prolonged androgen suppression and links to sepsis risk.

bioRxiv · Nov 27, 2019Physiology