Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 drives concurrent 11-oxygenated androgen excess
L. Schiffer, I. Oestlund, J. Snoep…·K.-H. Storbeck
This study shows that inhibiting HSD11B1 increases 11-ketotestosterone levels in adipose tissue and circulation, potentially offsetting benefits of reduced glucocorticoid activation in women.