Alkyne modified purines for assessing activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp.
A. Botnar, G. Lawrence, S. P. Maher, A. Vantaux, B. Witkowski, J. C. Shiau, E. F. Merino, D. De Vore, C. Yang, C. Murray, M. B. Cassera, J. W. Leahy, D. E. Kyle
This study develops alkyne-modified purines as a DNA synthesis marker to distinguish replicating and non-replicating Plasmodium stages, aiding in understanding dormancy mechanisms.
bioRxiv · Oct 12, 2021 · PreprintMicrobiology