B. Witkowski

Hemisynthetic derivatives of the natural alkaloid trilobine are fast-acting antimalarial compounds with sustained activity in multi-drug resistant P. falciparum isolates

Liver stage fate determination in Plasmodium vivax parasites: characterization of schizont growth and hypnozoite fating from patient isolates

This study investigates how P. vivax patient isolates and hepatocyte donor lots influence hypnozoite formation and schizont growth in liver stage cultures.

Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets

This study uses single-cell RNA sequencing to analyze P. vivax-infected hepatocytes, identifying transcriptomic differences between schizonts and hypnozoites and potential therapeutic targets.

Alkyne modified purines for assessing activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp.

This study develops alkyne-modified purines as a DNA synthesis marker to distinguish replicating and non-replicating Plasmodium stages, aiding in understanding dormancy mechanisms.

Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites

This study shows that Artemisia infusions inhibit Plasmodium stages without artemisinin, suggesting potential for new antimalarial compounds.

The tubovesicular network in Plasmodium vivax liver-stage hypnozoites and schizonts associates with host aquaporin 3

This study uses high-resolution microscopy to show AQP3 associates with the tubovesicular network in P. vivax hypnozoites and schizonts, revealing dynamic host-parasite interactions during liver-stage infection.