Author

A. Vantaux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Evolutionary Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:plant (other)· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

B. Witkowski· 5 shared S. P. Maher· 5 shared D. E. Kyle· 4 shared A. Cohuet· 3 shared K. R. Dabire· 3 shared T. Lefevre· 3 shared A. A. Ruberto· 2 shared C. A. Cooper· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersMicrobiology

B. Witkowski

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Multiple hosts, multiple impacts: the role of vertebrate host diversity in shaping mosquito life history and pathogen transmission

A. Vantaux, N. Moiroux, K. R. Dabire, A. Cohuet, T. Lefevre

This study examines how different vertebrate blood meal sources affect mosquito fitness and malaria parasite transmission, finding that blood meal type significantly impacts mosquito traits but not parasite development.

bioRxiv · Feb 10, 2023Evolutionary Biology

A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

S. P. Maher, M. A. Bakowski, A. Vantaux, E. L. Flannery, C. Andolina, M. Gupta, Y. Antonova-Koch, M. Argomaniz, C.-M. Monica, C. Brice, A. T. Chao, A. K. Chatterjee, W. T. Cheng, E. Chuenchob, C. A. Cooper, , McNama

The paper identifies epigenetic inhibitors active against Plasmodium vivax hypnozoites through drug repurposing screens, showing epigenetic pathways are critical for hypnozoite quiescence.

bioRxiv · Jan 31, 2023 · PreprintCell Biology

Liver stage fate determination in Plasmodium vivax parasites: characterization of schizont growth and hypnozoite fating from patient isolates

A. Vantaux, J. Peneau, C. A. Cooper, D. E. Kyle, B. Witkowski, S. P. Maher

This study investigates how P. vivax patient isolates and hepatocyte donor lots influence hypnozoite formation and schizont growth in liver stage cultures.

bioRxiv · Jun 16, 2022Microbiology

Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets

A. A. Ruberto, S. P. Maher, A. Vantaux, C. J. Joyner, C. Bourke, B. Balan, A. Jex, I. Mueller, B. Witkowski, D. E. Kyle

This study uses single-cell RNA sequencing to analyze P. vivax-infected hepatocytes, identifying transcriptomic differences between schizonts and hypnozoites and potential therapeutic targets.

bioRxiv · Feb 1, 2022Microbiology

Alkyne modified purines for assessing activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp.

A. Botnar, G. Lawrence, S. P. Maher, A. Vantaux, B. Witkowski, J. C. Shiau, E. F. Merino, D. De Vore, C. Yang, C. Murray, M. B. Cassera, J. W. Leahy, D. E. Kyle

This study develops alkyne-modified purines as a DNA synthesis marker to distinguish replicating and non-replicating Plasmodium stages, aiding in understanding dormancy mechanisms.

bioRxiv · Oct 12, 2021 · PreprintMicrobiology

Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites

K. Ashraf, S. Tajeri, C.-S. Arnold, N. Amanzougaghene, J.-F. Franetich, A. Vantaux, V. Soulard, M. Bordessoulles, G. Cazals, T. Bousema, G.-J. van Gemert, R. Le Grand, N. Dereuddre-Bosquet, J.-C. Barale, B. Witkowski, , D. Mazier

This study shows that Artemisia infusions inhibit Plasmodium stages without artemisinin, suggesting potential for new antimalarial compounds.

bioRxiv · Aug 10, 2021Microbiology

The tubovesicular network in Plasmodium vivax liver-stage hypnozoites and schizonts associates with host aquaporin 3

K. Sylvester, S. P. Maher, D. Posfai, M. K. Tran, M. C. Crawford, A. Vantaux, B. Witkowski, D. E. Kyle, E. R. Derbyshire

This study uses high-resolution microscopy to show AQP3 associates with the tubovesicular network in P. vivax hypnozoites and schizonts, revealing dynamic host-parasite interactions during liver-stage infection.

bioRxiv · Dec 9, 2020 · PreprintMicrobiology

Field evidence for manipulation of mosquito host selection by the human malaria parasite, Plasmodium falciparum

A. Vantaux, F. Yao, D. F. Hien, E. Guissou, B. K. Yameogo, L.-C. Gouagna, D. Fontenille, F. Renaud, F. Simard, C. Constantini, F. Thomas, K. Mouline, B. Roche, A. Cohuet, K. R. Dabire, T. Lefevre

The paper shows that Plasmodium falciparum increases mosquito anthropophagy in infectious females, enhancing parasite transmission.

bioRxiv · Nov 8, 2018Evolutionary Biology

Can malaria parasites manipulate the odour-mediated host preference of their mosquito vectors?

P. L. Nguyen, A. Vantaux, D. F. Hien, K. R. Dabire, B. Yameogo, L.-C. Gouagna, D. Fontenille, F. Renaud, F. Simard, C. Constantini, F. Thomas, A. Cohuet, T. Lefevre

This study investigates whether malaria parasites manipulate mosquito host choice toward suitable hosts, finding no effect on activation rate or odour preference in infected mosquitoes.

bioRxiv · Mar 7, 2017Evolutionary Biology