Fast Evolution of SOS-Independent Multi-Drug Resistance in Bacteria
L. Zhang, Y. Guan, Y. Y. Cheng, N. N. Cokcetin, A. Bottomley, A. Robinson, E. Harry, A. M. van Oijen, Q. P. Su, D. Jin
This study shows that Escherichia coli lacking RecA rapidly develops beta-lactam resistance through an SOS-independent mechanism involving oxidative stress and DNA repair defects.
bioRxiv · Mar 29, 2022Microbiology