Mitochondrial dysfunction triggers secretion of the immunosuppressive factor α-fetoprotein
K. A. Jett, Z. N. Baker, A. Hossain, A. Boulet, P. A. Cobine, S. Ghosh, P. Ng, O. Yilmaz, K. Barretto, J. DeCoteau, K. Mochoruk, G. Ioannou, C. Savard, S. Yuan, C. Lowden, , S. C. Leary
This study identifies a copper-linked signaling circuit triggered by mitochondrial dysfunction that leads to immune suppression via α-fetoprotein secretion.
bioRxiv · Jul 2, 2021 · PreprintCell Biology