Author

A. Brady

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

M. B. Lawrenz· 2 shared S. M. Uriarte· 2 shared A. Ansari· 1 shared A. Callaway· 1 shared A. Donaldson· 1 shared A. Garrett· 1 shared A. Hadonou· 1 shared A. Innes· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

M. B. Lawrenz

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Classification of Variants of Reduced Penetrance in High Penetrance Cancer Susceptibility Genes: Framework for Genetics Clinicians and Clinical Scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK)

Alice Garrett, Sophie Allen, Miranda Durkie, George J. Burghel, Rachel Robinson, Alison Callaway, Joanne Field, Bethan A. Frugtniet, Sheila Palmer-Smith, Jonathan Grant, Judith Pagan, Trudi McDevitt, Charlie F Rowlands, Terri Patricia McVeigh, Helen Hanson, , J. Williams

The paper develops a framework for classifying variants of reduced penetrance in cancer susceptibility genes to improve variant interpretation consistency.

Genetics in Medicine · Oct 24, 2024Peer-reviewedGenetic & Genomic Medicine

Distinct Mechanisms of T3SS Recognition Control LTB4 Synthesis in Neutrophils versus Macrophages

A. Brady, L. C. Mora Martinez, B. Hammond, H. Bodduluri, S. M. Uriarte, M. B. Lawrenz

This study identifies distinct signaling pathways in neutrophils and macrophages for T3SS-mediated LTB4 synthesis, revealing differences in immune cell responses to bacterial infections.

bioRxiv · Jul 1, 2024 · PreprintImmunology

Inhibition of type III secretion system induced leukotriene B4 production by Yersinia pestis: A mechanism for early immune evasion

A. Brady, A. R. Pulsifer, S. L. Price, K. R. Sheneman, K. R. Maddipati, S. R. Bodduluri, J. Pan, S. N. Rai, B. Haribabu, S. M. Uriarte, M. B. Lawrenz

This paper identifies how Yersinia pestis inhibits leukotriene B4 production, a key inflammatory lipid, to evade the host immune response during plague.

bioRxiv · Mar 13, 2023 · PreprintMicrobiology