A. Ansari

Quantifying evidence for phenotypic specificity (PP4) for syndromic phenotypes: Large-scale integration of rare germline FH variants from diagnostic laboratory testing for HLRCC (Hereditary Leiomyomatosis and Renal Cell Cancer) and renal cancer

The paper quantifies phenotypic specificity of rare FH variants in HLRCC and renal cancer using likelihood ratios from clinical and population data.

Classification of Variants of Reduced Penetrance in High Penetrance Cancer Susceptibility Genes: Framework for Genetics Clinicians and Clinical Scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK)

The paper develops a framework for classifying variants of reduced penetrance in cancer susceptibility genes to improve variant interpretation consistency.

Minimized Sample Consumption for Time-Resolved Serial Crystallography Applied to the Redox Cycle of Human NQO1

This paper demonstrates a method to reduce sample consumption in time-resolved serial crystallography by using segmented droplet generation and mix-and-inject approaches for studying NQO1's redox cycle.

Evidence for intrinsic DNA dynamics and deformability in damage sensing by the Rad4/XPC nucleotide excision repair complex

The paper investigates DNA dynamics and deformability in Rad4/XPC damage sensing using T-jump and FRET techniques, showing rapid fluctuations and unwound/bent conformations at lesion sites.

Design of SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model

The paper designs SARS-CoV-2 PLpro inhibitors that show antiviral efficacy in a mouse model against SARS-CoV-2 and its variants.

MicroRNA-541-3p alters lipoproteins to reduce atherosclerosis by degrading Znf101 and Casz1 transcription factors

This study identifies miR-541-3p as a regulator that reduces atherosclerosis by decreasing apoB and increasing apoA1 through degradation of Znf101 and Casz1 transcription factors.

Multiplexed microfluidic chip for cell co-culture

The paper introduces a microfluidic chip for co-culture studies that enables controlled paracrine signaling and high throughput.

A termination-independent role of Rat1 in cotranscriptional splicing

This study identifies a novel role of Rat1 in cotranscriptional splicing in yeast, showing it interacts with splicing factors and affects intron processing.

Global spread and evolutionary history of HCV subtype 3a

The paper uses host and virus genomic data to trace the global spread and evolutionary history of HCV subtype 3a, finding it originated in South Asia and spread through three independent events post-World War II.

Tethering-facilitated DNA 'opening' and complementary roles of β-hairpin motifs in the Rad4/XPC DNA damage sensor protein

This study shows Rad4/XPC can open undamaged DNA in solution without specific β-hairpin motifs and reveals dynamic conformations of open DNA through crystal structures and fluorescence analysis.

Light-induced modulation of DNA recognition by the Rad4/XPC damage sensor protein

This paper shows that light can control DNA binding by the Rad4/XPC repair complex using photoswitchable DNA, revealing structural changes in DNA upon binding.

Data from an electronic health informatics pipeline to describe clearance dynamics of Hepatitis B surface antigen (HBsAg) and e-Antigen (HBeAg) in chronic HBV infection

The paper describes an electronic health informatics pipeline that collects longitudinal clinical data on HBsAg and HBeAg clearance in chronic HBV infection, revealing demographic and treatment-related factors associated with clearance.

HBV vaccination and PMTCT as elimination tools in the presence of HIV: insights from a clinical cohort and dynamic model

This study evaluates HBV vaccination and PMTCT as tools for elimination in HIV-coinfected populations using a clinical cohort and dynamic model, showing potential for significant public health impact by 2030.

Static kinks or flexible hinges: conformational distributions of bent DNA bound to integration host factor mapped by fluorescence lifetime measurements

This study uses fluorescence lifetime measurements to show that IHF-DNA complexes exhibit conformational flexibility, with some DNA remaining unbent or partially bent despite IHF-induced kinking.

Quantitative mass imaging of single molecules in solution

This paper introduces a method to mass-image single biomolecules in solution with high precision and resolution, enabling the study of molecular interactions and assemblies.

Monovalent ions modulate the flux through multiple folding pathways of an RNA pseudoknot

This study investigates how monovalent ions affect the folding pathways of an RNA pseudoknot, showing that salt concentration modulates the flux between parallel folding pathways.