Author

T. Grothier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

E. Kokalaki· 2 shared I. Gannon· 2 shared J. Sillibourne· 2 shared M. Pule· 2 shared M. Robson· 2 shared S. Srivastava· 2 shared S. Thomas· 2 shared A. Bulek· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersImmunology

E. Kokalaki

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2 papers

Recent·Most cited

Enhancing CAR T cell therapy using Fab-Based Constitutively Heterodimeric Cytokine Receptors

M. Righi, I. Gannon, M. Robson, S. Srivastava, E. Kokalaki, T. Grothier, F. Nannini, C. Allen, B. Yuchen, J. Sillibourne, S. P. Cordoba, S. Thomas, M. Pule

This paper introduces a dimerization domain from IgG1 antibodies to create engineered cytokine receptors that mimic natural heterodimerization, enhancing CAR T cell therapy efficacy.

Cancer Immunology Research · Jun 23, 2023Peer-reviewedImmunology

Exploration of T-cell immune responses by expression of a dominant-negative SHP1 and SHP2

J. Taylor, A. Bulek, I. Gannon, M. Robson, E. Kokalaki, T. Grothier, C. McKenzie, M. El-Kholy, M. Stavrou, C. Traynor-White, W. C. Lim, P. Panagiotou, S. Srivastava, V. Baldan, J. Sillibourne, , S. Thomas

This study investigates the role of SHP1 and SHP2 in T-cell immunosuppression by expressing truncated variants and shows that dSHP2 can alleviate PD1-mediated suppression in CAR T cells.

bioRxiv · Apr 26, 2023Immunology