Cancer BiologybioRxiv
Mechanisms of Resistance to CAR-T cell Immunotherapy: Insights from a Mathematical Model
D. S. Santurio, E. A. Paixao, L. R. C. Barros…·A. C. Fassoni
The paper develops a mathematical model to study antigen-mediated resistance mechanisms in CAR-T cell therapy, showing how antigen expression levels affect treatment outcomes in hematological cancers.
DOI 10.1016/j.apm.2023.08.029