HLA topography enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients
J. T. Killian, R. G. King, A. C. Lucander, J. L. Kizziah, C. F. Fucile, R. Diaz-Avalos, S. Qiu, A. Silva-Sanchez, B. J. Mousseau, K. J. Macon, A. R. Callahan, G. Yang, M. E. Hossain, J. Akther, J. A. Houp, , F. E. Lund
The paper identifies an immunodominant B cell response targeting specific HLA residues in transplant recipients, suggesting antigenic topography drives antibody-mediated rejection.
bioRxiv · Mar 31, 2023 · PreprintImmunology