G. Yang

Association study of Plasmodium falciparum Acetyl-CoA Synthetase Mutations S868G and V949I with antimalarial drugs

This study investigates the association of PfACAS mutations S868G and V949I with antimalarial drug resistance using whole-genome sequencing and CRISPR/Cas9-engineered parasites.

Human microbiome-derived peptide affects the development of experimental autoimmune encephalomyelitis via molecular mimicry

This study identifies a gut microbiome-derived peptide that mimics a myelin antigen and induces experimental autoimmune encephalomyelitis in mice.

An expanded metabolic pathway for androgen production by host-associated bacteria

This study identifies a bacterial pathway for androgen production, showing that gut and urinary bacteria can convert androstenedione to epitestosterone and testosterone, which promote prostate cancer growth.

Acetyl-CoA Synthetase Mutations S868G and V949I Do Not Confer Resistance to Antimalarial Drugs in vitro in Plasmodium falciparum.

This study investigates whether mutations in PfACAS confer antimalarial drug resistance by engineering parasite lines with these mutations and testing their drug susceptibility in vitro.

Zinc finger transcription factors BnaSTOP2s regulate sulfur metabolism and confer resistance to Sclerotinia sclerotiorum in Brassica napus

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

This paper identifies eIF4A as a key regulator of ER translation in breast cancer and shows that inhibiting eIF4A, either alone or with fulvestrant, suppresses ER expression and tumor growth in advanced ER+ breast cancer.

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.

Fragility of ER homeostatic regulation underlies haploid instability in human somatic cells

This study identifies ER stress-induced proteotoxicity as a key factor causing haploid instability in human somatic cells, showing that haploids are more prone to apoptosis due to inefficient proteostasis.

Transcranial Photobiomodulation on the Left Prefrontal Cortex Enhances Mandarin Chinese L1 and L2 Complex Sentence Processing Performances

This study shows that transcranial photobiomodulation over the left prefrontal cortex improves sentence processing in Mandarin Chinese L1 and L2 speakers without affecting working memory.

E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation

This study identifies ASB3 as an E3 ligase that suppresses antiviral immunity by ubiquitinating and degrading MAVS, thereby inhibiting IFN-I responses and promoting viral replication.

AhR ligands from LGG metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection

This study shows LGG metabolites activate ILC3 cells via AhR to produce IL-22, which prevents PEDV infection in piglets by enhancing intestinal cell proliferation and STAT3 signaling.

Biosurfactant stabilized nanoemulsions as multifunctional magnetically targeted delivery vehicles

This paper develops biosurfactant-stabilized magnetic nanoemulsions for targeted drug delivery, showing enhanced cell uptake in cancer and macrophage cells under magnetic fields.

IsoVEM: Isotropic Reconstruction for Volume Electron Microscopy Based on Transformer

The paper introduces IsoVEM, a transformer-based algorithm for isotropic reconstruction in volume electron microscopy, improving axial resolution and repairing damaged sections.

ER mediates spatial regulation of lysosome-endosome interactions via motion switch at junction sites

The paper investigates how lysosomes and endosomes interact with the ER through spatial regulation, revealing a mechanism involving actin cytoskeleton condensation and the VAP-STARD3-YWHAH pathway.

Exposure to titanium dioxide nanoparticles accelerates abnormal fat deposition through the mediation of the ROS via the AGE-RAGE signaling pathway in mice

This study shows that titanium dioxide nanoparticles induce fat deposition in mice by increasing ROS and activating the AGE-RAGE pathway, with NAC as a potential therapeutic.

ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota

This study shows ASB3 worsens inflammatory bowel disease by destabilizing TRAF6 and altering gut microbiota, suggesting ASB3 inhibition could be a therapeutic strategy.

Transcriptome mining of RNA viruses (family Totiviridae) in Eimeria necatrix and Eimeria stiedai

The paper identifies and analyzes two new Totiviridae viruses in Eimeria species, revealing phylogenetic insights and suggesting a new genus classification.

Genetic basis of expression and splicing underlying spike architecture in wheat (Triticum aestivum L.)

This study identifies eQTLs and sQTLs associated with spike architecture in wheat, revealing genetic factors that regulate gene expression and splicing related to yield traits.

HLA topography enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients

The paper identifies an immunodominant B cell response targeting specific HLA residues in transplant recipients, suggesting antigenic topography drives antibody-mediated rejection.

A high-throughput multiplex array for antigen-specific serology with automated analysis.

The paper describes a high-throughput CBA system for antigen-specific serology with automated analysis tools to quantify IgM, IgA, and IgG concentrations.

Development of Fully Human, Bispecific Antibodies that Effectively Block Omicron Variant Pseudovirus Infections

This study develops fully human bispecific antibodies that effectively block Omicron variant pseudovirus infections, showing improved neutralization compared to monoclonal antibodies.

Single-cell transcriptional analysis of lamina propria lymphocytes in the jejunum reveals ILC-like cells in pigs

The paper identifies and characterizes ILC-like cells in porcine jejunum using scRNA-seq and flow cytometry, revealing subtype classifications and shared features with human ILCs.

Structural basis for BIRC6 to balance apoptosis and autophagy

This study reveals the structural basis of BIRC6's role in balancing apoptosis and autophagy by showing its dimeric structure and interactions with Smac/DIABLO, caspase 3, HtrA2, and LC3.

Targeting TR4-induced RCC cells-derived exosomally initiated signaling increases Sunitinib efficacy

This study shows TR4 promotes RCC cell-derived exosomal ADAM15, which activates EGFR in endothelial cells and reduces Sunitinib efficacy, and demonstrates that targeting this pathway enhances Sunitinib effectiveness.

Spatial Localization Ability of Planarians Identified Through the Light Maze Paradigm

This paper demonstrates that planarians can navigate to a previously recognized location in a new maze, indicating they have spatial localization ability.

Diving Behavior Reveals Humidity Sensing Ability of Water Deprived Planarians

This study shows that aquatic planarians can sense humidity and use this ability to find water during drought by diving behavior.

Programmable acetylation modification of bacterial proteins by a Cas12a-guided acetyltransferase

This study develops a TPA system using Cas12a and bacterial acetylase At2 to enable in situ targeted protein acetylation in bacteria, demonstrating its specificity and efficiency for modification studies.

Tumor subclones, where are you?

This study compares bulk and single-cell mutational analysis to assess tumor clonal structure, finding that bulk analysis underestimates subclonal complexity and dynamic evolution.

A Multifunctional Anchor for Multimodal Expansion Microscopy

This paper introduces a multifunctional anchor for expansion microscopy, enabling simultaneous imaging of multiple biomolecules with reduced cost and complexity.

Role of Paravertebral muscle myostatin upregulation in the development of idiopathic scoliosis

This study identifies myostatin upregulation in paravertebral muscle cells as a driver of oxidative stress and apoptosis, contributing to idiopathic scoliosis development.