F. E. Lund

HLA topography enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients

The paper identifies an immunodominant B cell response targeting specific HLA residues in transplant recipients, suggesting antigenic topography drives antibody-mediated rejection.

A high-throughput multiplex array for antigen-specific serology with automated analysis.

The paper describes a high-throughput CBA system for antigen-specific serology with automated analysis tools to quantify IgM, IgA, and IgG concentrations.

CD38 promotes hematopoietic stem cell dormancy via c-Fos

This study identifies CD38 as a marker for dormant hematopoietic stem cells and shows it promotes dormancy through the cADPR/Ca2+/c-Fos/p57Kip2 pathway.

Intranasal self-amplifying RNA SARS-CoV-2 vaccine produces protective respiratory and systemic immunity and prevents viral transmission

This study compares intranasal and intramuscular delivery of a self-amplifying RNA SARS-CoV-2 vaccine, showing that intranasal delivery induces mucosal immunity and reduces viral transmission.

Chitinase-3-like 1 regulates TH2 cells, TFH cells and IgE following helminth infection

This study shows that ChI3L1 is required for TH2, TFH, and IgE responses following helminth infection and vaccination, but not for IgG1 responses.

A Non-redundant Role for T cell-derived IL-22 in Antibacterial Defense of Colonic Crypts

This study shows that T cell-derived IL-22 is essential for antibacterial defense and damage control in intestinal crypts, despite ongoing ILC3-derived IL-22 production.

Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans

The paper identifies T-bethi Bmem cells as predictors of long-lived antibody responses to influenza vaccination in humans.

Spatial heterogeneity of glioblastoma cells reveals sensitivity to NAD+ depletion at tumor edge

This study identifies clonal subpopulations in glioblastoma core and edge lesions and shows that NAD+ depletion via CD38 inhibition reduces tumor edge formation.

Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice

This study shows that AdCOVID, an intranasal vaccine, induces both systemic and mucosal immunity against SARS-CoV-2 in mice.

IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation

This study shows IFNγ promotes T-bet expressing B cell differentiation and epigenetic reprogramming in humans, enhancing IL-21-driven antibody production.