S. Qiu

Opto-chemogenetic inhibition of L-type CaV1 channels in neurons through a membrane-assisted molecular linkage

This paper develops a method to inhibit L-type CaV1 channels in neurons using opto-chemogenetic tools, showing acute and potent inhibition through membrane-assisted molecular linkage.

Katanin, kinesin-13 and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes

The paper shows that katanin, kinesin-13, and ataxin-2 prevent premature interaction between maternal and paternal genomes in C. elegans zygotes by limiting sperm content movement and maintaining cohesion.

Effect of Electroacupuncture Pretreatment on Cognitive Impairment and Mitophagy in Aging Model Rats and its mechanism

This study investigates how electroacupuncture pretreatment affects cognitive impairment and mitophagy in aging rats, finding it improves cognitive function by enhancing mitophagy and mitochondrial function.

General Capillary Endothelial Cells Undergo Reprogramming into Arterial Endothelial Cells in Pulmonary Hypertension through HIF-2α/Notch4 Pathway

Identification and classification of the genomes of novel Microviruses in a poultry slaughterhouse

This study identifies 98 novel microvirus genomes from a poultry slaughterhouse, classifies them into 6 new subfamilies and 3 higher-level units, and expands their known host range.

Bioprocess optimization enables enhanced protopanaxadiol production in yeast

This study optimizes bioprocess conditions to enhance protopanaxadiol production in yeast using Design of Experiment, achieving a 7.5-fold increase in yield.

A telomere-to-telomere genome assembly of Zhonghuang 13, a widely-grown soybean variety from the original center of Glycine max

This paper presents the first telomere-to-telomere genome assembly of the soybean cultivar Zhonghuang 13, resolving gaps and identifying novel genes and structural variations.

Expansion Strategy-Driven Micron-Level Resolution Mass Spectrometry Imaging of Lipids in Mouse Brain Tissue

This paper introduces a method to enhance spatial resolution in lipid mass spectrometry imaging of mouse brain tissue by using a swellable polyelectrolyte gel, achieving subcellular-level visualization.

Mitochondrial DNA released by senescent cells triggers immunosuppression in cancer

This study shows that mtDNA released by senescent cells triggers immunosuppression via PMN-MDSCs, and inhibiting this pathway enhances therapy-induced senescence in cancer.

HLA topography enforces shared and convergent immunodominant B cell and antibody alloresponses in transplant recipients

The paper identifies an immunodominant B cell response targeting specific HLA residues in transplant recipients, suggesting antigenic topography drives antibody-mediated rejection.

A high-throughput multiplex array for antigen-specific serology with automated analysis.

The paper describes a high-throughput CBA system for antigen-specific serology with automated analysis tools to quantify IgM, IgA, and IgG concentrations.

Partial sex linkage and linkage disequilibrium on the guppy sex chromosome

The paper analyzes PoolSeq data from guppy populations to assess sex linkage and recombination suppression, finding evidence of linkage disequilibrium but no consistent male-specific variants.

Identification of candidate virulence loci in Striga hermonthica, a devastating parasite of African cereal crops

The paper identifies candidate virulence loci in Striga hermonthica by analyzing allele frequency differences between resistant and susceptible hosts.

Population model of Temnothorax albipennis as a distributed dynamical system: I. self-consistent threshold is an emergent property in combination of quorum sensing and chemical perception of limited resource

The paper models ant house-hunting behavior as a distributed dynamical system, showing that a self-consistent threshold emerges from quorum sensing and chemical perception of limited resources.

Population model of Temnothorax albipennis as a distributed dynamical system II: secret of "chemical reaction" in collective house-hunting in ant colonies is unveiled by operator methods

The paper models ant collective house-hunting as a distributed dynamical system using operator methods, deriving differential equations that describe the stochastic process and provide testable predictions.

Metabolic characteristics of taste differences under the soil and hydroponic cultures of sweet potato leaves by using non-targeted metabolomics

This study compares the metabolic profiles of sweet potato leaves grown in soil versus hydroponic systems to identify metabolites associated with taste quality differences.

Locomotor performance and CNS responses to hypoxia in a cyclic nucleotide-gated channel mutant of adult Drosophila

This study investigates the role of CNGL channels and cGMP signaling in hypoxia response in adult Drosophila, finding impaired recovery and altered CNS K+ dynamics in CNGL mutants.

Changes in nitrogen pools in the maize-soil system after urea or straw application to a typical intensive agricultural soil: A 15N tracer study

This study compares nitrogen dynamics in maize-soil systems with urea and urea-straw treatments, finding that straw enhances nitrogen availability through rhizosphere interactions.

Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 in mice

This study shows that AdCOVID, an intranasal vaccine, induces both systemic and mucosal immunity against SARS-CoV-2 in mice.

Potentiating the anti-tumor response of tumor infiltrated T cells by NAD+ supplementation

NAD+ supplementation enhances T cell activation and tumor-killing capacity in immunotherapies.

Genome profiles of lymphovascular breast cancer cells reveal multiple clonally differentiated outcomes with multi-regional LCM and G&T-seq

This study isolates lymphovascular breast cancer cells using LCM and G&T-seq to identify three distinct clonal pathways associated with different survival outcomes and ribosomal protein downregulation as a poor prognosis marker.

A Single-Cell Immune Atlas of Triple Negative Breast Cancer Reveals Novel Immune Cell Subsets

The paper performs single-cell RNA sequencing on TNBC tumors to identify novel immune cell subsets and their associations with survival and TCR signaling.

The common neoantigens in colorectal cancer are predicted and validated to be presented or immunogenic

The paper predicts and validates common neoantigens in colorectal cancer that are both presented and immunogenic, identifying potential universal targets for immunotherapy.

Assessment of the optimum fertilizer rates and planting density for soybean production in China

The paper evaluates optimal fertilizer rates and planting density for soybean production in China using field experimental data, finding varying optimal rates for spring and summer soybean.

Pairwise learning of MRI scans using a convolutional Siamese network for prediction of knee pain

This paper uses a convolutional Siamese network to predict bilateral knee pain from MRI scans, achieving 70.1% mean accuracy.

Molecular profiles and mutation burden analysis in Chinese patients with gastric carcinoma

This study analyzes molecular profiles and mutation burden in Chinese gastric carcinoma patients, identifying gene alterations and genomic regions linked to tumor burden and prognosis.

5-Hydroxymethylcytosines from Circulating Cell-free DNA as Diagnostic and Prognostic Markers for Hepatocellular Carcinoma

This study develops a 5-hydroxymethylcytosine (5hmC) diagnostic model from circulating cell-free DNA to detect hepatocellular carcinoma with high accuracy and prognostic value.

Mixed-cropping systems of different rice cultivars have grain yield and quality advantages over mono-cropping systems

This study shows mixed-cropping of different rice cultivars increases grain yield and quality compared to mono-cropping systems.

Persistent one-way walking in a circular arena in Drosophila melanogaster Canton-S strain

This study shows that wild-type Drosophila melanogaster exhibit persistent one-way walking in a circular arena, while white-eyed mutants show frequent directional changes, with the w+ locus promoting persistent one-way walking.

The white gene controls copulation success in Drosophila melanogaster

This study identifies the white gene as controlling copulation success in Drosophila melanogaster, independent of its role in eye color.