Cancer BiologybioRxiv
Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation
N. Rodrigues Mantuano, M. A. Stanczak, I. de Araujo Oliveira…·H. Laubli
This study shows hyperglycemia promotes cancer immune evasion by increasing O-GlcNAcylation in tumor-associated macrophages, shifting their polarization to a pro-tumorigenic M2-like phenotype.
DOI 10.1158/2326-6066.cir-19-0904