Author

A. Zippelius

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 3 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3

Frequent Co-Authors

H. Laubli· 3 shared M. A. Stanczak· 3 shared M. P. Trefny· 3 shared N. Kirchhammer· 3 shared D. Lardinois· 2 shared G. Monaco· 2 shared H. Laeubli· 2 shared N. Rodrigues Mantuano· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

H. Laubli

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Multimodal single-cell profiling of T cell specificity and reactivity in lung cancer

F. Bieberich, R. Vazquez-Lombardi, H. Jin, K.-L. Hong, P. Herzig, M. Trefny, M. Trueb, H. Laubli, D. Lardinois, K. Mertz, M. Matter, A. Zippelius, S. T. Reddy

This study uses multimodal single-cell profiling to analyze T cell specificity and reactivity in lung cancer patients, identifying tumor- and virus-reactive T cells and their functional states.

bioRxiv · Oct 4, 2023 · PreprintImmunology

Engagement of sialylated glycans with Siglec receptors on myeloid suppressor cells inhibit anti-cancer immunity via CCL2

R. Wieboldt, E. Carlini, L. Chia-wei, A. Boersch, A. Zingg, D. Lardinois, P. Herzig, L. Don, A. Zippelius, H. Laeubli, N. Rodrigues Mantuano

This study shows that sialylated glycans on myeloid suppressor cells interact with Siglec receptors to suppress anti-cancer immunity through CCL2-mediated mechanisms.

bioRxiv · Jun 29, 2023 · PreprintImmunology

13C tracer analysis reveals the landscape of metabolic checkpoints in human CD8+ T cell differentiation

A. Kirchmair, N. Nemati, G. Lamberti, M. P. Trefny, A. Krogsdam, A. Siller, P. Hörtnagl, P. Schumacher, S. Sopper, A. M. Sandbichler, A. Zippelius, B. Ghesquiere, Z. Trajanoski

This study uses 13C metabolomics and transcriptomics to analyze metabolic changes in CD8+ T cells during differentiation, identifying key metabolic checkpoints and their role in exhaustion.

bioRxiv · May 18, 2023 · PreprintImmunology

Tumor-educated monocytes suppress T cells via adenosine and depletion of adenosine in the tumor microenvironment with adenosine deaminase enzyme promotes response to immunotherapy

O. S. Sarkar, H. Donninger, N. Al Rayyan, L. C. Chew, B. Stamp, X. Zhang, A. Whitt, C. Li, M. Hall, R. A. Mitchell, A. Zippelius, J. Eaton, J. A. Chesney, K. Yaddanapudi

This study shows that tumor-educated monocytes suppress T cells via adenosine and that depleting adenosine with PEG-ADA enhances immunotherapy response in preclinical models.

bioRxiv · Jun 22, 2022 · PreprintCell Biology

Adaptive anti-tumor immunity is orchestrated by a population of CCL5-producing tissue-resident NK cells

N. Kirchhammer, M. P. Trefny, M. Natoli, D. Bruecher, S. N. Smith, F. Werner, V. Koch, D. Schreiner, E. Bartoszek, M. Buchi, M. Schmid, D. Breu, K. P. Hartmann, P. Zaytseva, D. S. Thommen, , A. Zippelius

The paper shows that CCL5-producing tissue-resident NK cells are critical for IL-12-mediated anti-tumor immunity and that CCL5 delivery can overcome resistance in tumors with low trNK cell infiltration.

bioRxiv · May 27, 2021 · PreprintImmunology

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade

M. A. Stanczak, N. R. Mantuano, N. Kirchhammer, D. E. Sanin, J. Wang, M. P. Trefny, G. Monaco, M. A. Gray, A. Petrone, A. S. Kashyap, K. Glatz, B. Kasenda, K. Normington, J. Broderick, L. Peng, , H. Laeubli

This study shows that targeting cancer glycosylation with an antibody-sialidase conjugate repolarizes tumor-associated macrophages and enhances immune checkpoint blockade efficacy in mouse models.

bioRxiv · Apr 11, 2021Immunology

Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylation

N. Rodrigues Mantuano, M. A. Stanczak, I. de Araujo Oliveira, N. Kirchhammer, A. Filardy, G. Monaco, R. C. Santos, A. Carlos Fonseca, M. Fontes, C. de Souza Bastos, W. B. Dias, A. Zippelius, A. R. Todeschini, H. Laubli

This study shows hyperglycemia promotes cancer immune evasion by increasing O-GlcNAcylation in tumor-associated macrophages, shifting their polarization to a pro-tumorigenic M2-like phenotype.

bioRxiv · Nov 5, 2019Cancer Biology