Cancer BiologyBloodPeer-reviewed
Core binding factor leukemia hijacks T-cell prone PU.1 antisense promoter
E. van der Kouwe, G. Heller, A. Czibere…·P. B. Staber
The paper shows that CBF fusions in AML activate the PU.1 antisense promoter, reducing sense PU.1 transcription and blocking myeloid differentiation, similar to T-cell differentiation.
DOI 10.1182/blood.2020008971