A. D'Mello

Streamlining Marker-less Allelic Replacement in Streptococcus pneumoniae Through a Single Transformation Step Strategy: easyJanus

This paper introduces a streamlined method for marker-less allelic replacement in Streptococcus pneumoniae using a single transformation step, reducing complexity and false positives compared to traditional methods.

Unveiling the Immune Dynamics of Neisseria Persistent Oral Colonization: A Roadmap for Innovative Vaccine Strategies

This study investigates immune dynamics during Neisseria musculi colonization in mice, identifying key genes and pathways for immune homeostasis and offering insights for vaccine development.

Group B Streptococcus Cas9 variants provide insight into programmable gene repression and CRISPR-Cas transcriptional effects

The paper investigates how GBS Cas9 variants affect genome-wide transcription and shows nonspecific protospacer adjacent motif binding drives these effects without altering virulence.

Influenza A virus modulation of Streptococcus pneumoniae infection using ex vivo transcriptomics in a human primary lung epithelial cell model reveals differential host glycoconjugate uptake and metabolism

This study uses ex vivo transcriptomics to show that influenza A virus infection enhances pneumococcal growth and alters bacterial metabolism in human lung epithelial cells.

In vitro phenotypic and transcriptomic variation in Neisseria musculi morphotypes correlate with colonization variability and persistence in vivo

This study compares in vitro and in vivo phenotypes of two Neisseria musculi morphotypes, showing differences in colonization patterns and persistence in mice.