J. R. Lane

This study shows PspA-mediated aggregation of Streptococcus pneumoniae enhances desiccation survival on fomites and transmission to new hosts.

This study uses ex vivo transcriptomics to show that influenza A virus infection enhances pneumococcal growth and alters bacterial metabolism in human lung epithelial cells.

This paper develops ML321, a highly selective D2 dopamine receptor antagonist, showing efficacy in animal models predictive of atypical antipsychotic activity with fewer side effects.

The paper identifies distinct antagonist-bound inactive states in dopamine D2 and D3 receptors, showing conformational diversity with implications for drug discovery.