E. Martinez

3D micropatterned traction force microscopy: a technique to control three-dimensional cell shape while measuring cell-substrate force transmission.

This paper introduces 3D-TFM to measure cell-substrate forces in 3D environments and shows cells switch from contractile to extensile behavior as volume decreases.

In a nutshell: pistachio genome and kernel development

This study generates a chromosome-scale pistachio genome and analyzes kernel development stages to understand molecular pathways affecting nutritional quality.

Streamlining Marker-less Allelic Replacement in Streptococcus pneumoniae Through a Single Transformation Step Strategy: easyJanus

This paper introduces a streamlined method for marker-less allelic replacement in Streptococcus pneumoniae using a single transformation step, reducing complexity and false positives compared to traditional methods.

Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancer

This paper identifies NGL-1 as a stromal immunomodulator in pancreatic cancer that promotes tumor growth by modulating the tumor microenvironment through TGF-β and transcription factor pathways.

The multifunction Coxiella effector Vice stimulates macropinocytosis and interferes with the ESCRT machinery

This study identifies the Coxiella effector Vice as a protein that manipulates host cell lipid composition and cellular pathways to form the Coxiella-containing vacuole.

Laser patterning bioprinting using a light sheet-based system equipped with light sheet imaging produces long-term viable skin constructs

This paper introduces a light sheet-based bioprinter with live imaging that produces long-term viable skin constructs with high resolution.

Genomic markers of drug resistance in Mycobacterium tuberculosis populations with minority variants

The paper identifies drug-resistant minority variants in Mycobacterium tuberculosis populations and shows their association with mixed strain populations and treatment outcomes.

Influenza A virus modulation of Streptococcus pneumoniae infection using ex vivo transcriptomics in a human primary lung epithelial cell model reveals differential host glycoconjugate uptake and metabolism

This study uses ex vivo transcriptomics to show that influenza A virus infection enhances pneumococcal growth and alters bacterial metabolism in human lung epithelial cells.

Engineered superinfective Pf phage prevents dissemination of Pseudomonas aeruginosa in a mouse burn model

The paper engineers a superinfective Pf phage to prevent Pseudomonas aeruginosa dissemination in burn wounds, achieving bacterial clearance and survival in mice.

Modelling biochemical gradients in vitro to control cell compartmentalization in a microengineered 3D model of the intestinal epithelium

The paper develops a 3D in vitro intestinal model with controlled biochemical gradients to study cell compartmentalization and its response to niche factors.

Mitochondrial dysfunction promotes alternative gasdermin D-mediated inflammatory cell death and susceptibility to infection

This study shows that mitochondrial dysfunction caused by Lrrk2G2019S promotes non-pyroptotic cell death via GSDMD and increases susceptibility to infection.

Pseudomonas aeruginosa synthesizes the autoinducers of its oxylipin-dependent quorum sensing system extracellularly

This study shows that Pseudomonas aeruginosa synthesizes oxylipin autoinducers extracellularly via the Xcp type II secretion system, revealing a novel mechanism for quorum sensing and biofilm formation.

Fibroblast alignment coordinates epithelial migration and maintains intestinal tissue integrity

This study shows that fibroblast alignment enhances directed migration of intestinal epithelia and maintains tissue integrity through physical and biochemical interactions.

Capsule protects against intracellular killing and enables vascular endothelial cell translocation during invasive pneumococcal disease

This study shows that pneumococcal capsule protects bacteria from oxidative stress in host cells and enhances disease severity by promoting intracellular survival and translocation.

The Coxiella burnetii secreted protein kinase CstK influences vacuole development and interacts with the GTPase-activating protein TBC1D5

This study identifies CstK, a Coxiella burnetii kinase, as an effector that interacts with TBC1D5 to regulate vacuole formation and intracellular replication.