Tryptophan residues in TDP-43 and SOD1 mediate the cross-seeding and toxicity of SOD1
E. Pokrishevsky, M. G. Duval, L. McAlary, S. Louadi, S. Pozzi, A. Y. Roman, S. S. Plotkin, A. Dijkstra, J.-P. Julien, W. T. Allison, N. R. Cashman
This study identifies tryptophan residues in SOD1 and TDP-43 that mediate cross-seeding and toxicity in ALS, suggesting a druggable target for therapeutic intervention.
bioRxiv · Jul 27, 2020 · PreprintCell Biology