Author

L. McAlary

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Organism:zebrafish· 1

Frequent Co-Authors

J. J. Yerbury· 2 shared A. Dijkstra· 1 shared A. K. Walker· 1 shared A. Y. Roman· 1 shared D. Cox· 1 shared E. Pokrishevsky· 1 shared G. S. Wright· 1 shared H. Ecroyd· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

J. J. Yerbury

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Author profile →

3 papers

Recent·Most cited

A copper chaperone-mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis

L. McAlary, V. K. Shephard, G. S. Wright, J. J. Yerbury

This study shows that combining CuATSM and ebselen reduces SOD1 aggregation and cell death in a cell model of ALS.

bioRxiv · Feb 22, 2021 · PreprintBiochemistry

Tryptophan residues in TDP-43 and SOD1 mediate the cross-seeding and toxicity of SOD1

E. Pokrishevsky, M. G. Duval, L. McAlary, S. Louadi, S. Pozzi, A. Y. Roman, S. S. Plotkin, A. Dijkstra, J.-P. Julien, W. T. Allison, N. R. Cashman

This study identifies tryptophan residues in SOD1 and TDP-43 that mediate cross-seeding and toxicity in ALS, suggesting a druggable target for therapeutic intervention.

bioRxiv · Jul 27, 2020 · PreprintCell Biology

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal-like cells

R. San Gil, D. Cox, L. McAlary, T. Berg, A. K. Walker, J. J. Yerbury, L. Ooi, H. Ecroyd

This study shows that neurodegenerative disease-associated protein aggregates fail to induce the heat shock response in neuronal-like cells, unlike non-pathogenic aggregation-prone proteins.

bioRxiv · Jan 6, 2020Cell Biology