Cell BiologybioRxivPreprint
Tryptophan residues in TDP-43 and SOD1 mediate the cross-seeding and toxicity of SOD1
E. Pokrishevsky, M. G. Duval, L. McAlary…·N. R. Cashman
This study identifies tryptophan residues in SOD1 and TDP-43 that mediate cross-seeding and toxicity in ALS, suggesting a druggable target for therapeutic intervention.
DOI 10.1101/2020.07.27.224188