Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions
A. Song, Z. Hazlett, D. Abeykoon, J. Dortch, A. Dillon, J. Curtiss, S. B. Martinez, C. P. Hill, C. Yu, L. Huang, D. Fushman, R. E. Cohen, T. Yao
This study shows UCH37 deubiquitinates branched ubiquitin chains, enhancing proteasome clearance of stress-induced inclusions.
bioRxiv · Aug 17, 2021Biochemistry