Author

D. Fushman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

D. Abeykoon· 2 shared A. Dillon· 1 shared A. Guseman· 1 shared A. JoachimiakiD· 1 shared A. N. Naganathan· 1 shared A. Sinha· 1 shared A. Song· 1 shared A. Thakur· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersBiophysics

D. Abeykoon

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Conformational Tuning Shapes the Balance between Functional Promiscuity and Specialization in Paralogous Plasmodium Acyl-CoA Binding Proteins

R. Dani, W. Pawloski, D. K. Chaurasiya, N. S. Srilatha, S. Agarwal, D. Fushman, A. N. Naganathan

This study investigates how sequence differences in paralogous Plasmodium ACBPs shape their conformational behavior and functional promiscuity.

bioRxiv · May 12, 2023 · PreprintBiophysics

The Symmetry and Asymmetry Behind Histone Folding Across Eukarya and Archaea

H. Zhao, H. Wu, A. Guseman, D. Abeykoon, C. M. Camara, Y. Dalal, D. Fushman, G. Papoian

The paper uses molecular dynamics and AI to show eukaryotic histones can form stable homodimers, with disordered tails favoring heterotypic dimers.

bioRxiv · Oct 15, 2022 · PreprintBiophysics

Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin

P. M. Wydorski, J. Osipiuk, B. T. Lanham, C. Tesar, M. Endres, E. Engle, R. Jedrzejczak, V. Mullapudi, K. Michalska, K. Fidelis, D. Fushman, A. Joachimiak, L. A. Joachimiak

This study identifies how SARS-CoV-2 PLpro selectively binds human ISG15 and K48-linked di-ubiquitin through dual domain recognition, revealing potential drug targets.

bioRxiv · Sep 15, 2021 · PreprintBiophysics

Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

A. Song, Z. Hazlett, D. Abeykoon, J. Dortch, A. Dillon, J. Curtiss, S. B. Martinez, C. P. Hill, C. Yu, L. Huang, D. Fushman, R. E. Cohen, T. Yao

This study shows UCH37 deubiquitinates branched ubiquitin chains, enhancing proteasome clearance of stress-induced inclusions.

bioRxiv · Aug 17, 2021Biochemistry

Rub1/NEDD8, a ubiquitin-like modifier, is also a ubiquitin modifier

S. Zerath Gurevich, A. Sinha, J. Longworth, R. K. Singh, B. E. Lemma, A. Thakur, O. Popp, D. Kornitzer, N. Reis, M. Scheffner, G. Dittmar, E. Pick, D. Fushman, M. H. Glickman

This paper shows that a single amino acid swap at position 72 can switch the substrate specificity of Rub1/NEDD8 and ubiquitin, revealing their distinct roles in cellular modification pathways.

bioRxiv · Jun 18, 2020 · PreprintBiochemistry